Evidence map›Paper›PMID 34895048›Full record

ArticleBioengineered2021

MicroRNA-98-5p modulates cervical cancer progression via controlling PI3K/AKT pathway.

RongXin Xiao, Hong Wang, Biao Yang

Open access · goldAbstract read
In one paragraph

Article in Bioengineered, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

RongXin XiaoDepartment of Gynaecology, Funing People's Hospital, Yancheng City, JiangSu Province, China.
Hong WangDepartment of Gynaecology, Funing People's Hospital, Yancheng City, JiangSu Province, China.
Biao YangDepartment of Gynaecology, Funing People's Hospital, Yancheng City, JiangSu Province, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To probe into the potential mechanism of microRNA (miR)-98-5p inhibiting the biological progress of cervical cancer (CC) cells via regulating PI3K/Akt pathway. Reverse transcription quantitative polymerase chain reaction was applied to detect miR-98-5p expression in CC tissues and cell lines; Cell counting kit-8 and Edu analysis were performed for checking cell proliferation, flow cytometry for cell apoptosis, transwell for cell invasion and migration, Western blot for proliferation-related proteins Ki67 and Proliferating cell nuclear antigen expression, apoptosis-related proteins Bcl-2 and Bax expression, epithelial-mesenchymal transition (EMT)-related proteins Snail, matrix metalloproteinase-3, E-cadherin and N-cadherin expression, as well as PI3K/Akt pathway-related proteins PTEN, PI3K as well as Akt expression levels, and the nude mouse tumor xenograft experiment was applied to verify

Indexed as

Disease ProgressionAnimalsApoptosisCell Line, TumorCell MovementCell ProliferationChromobox Protein Homolog 5Epithelial-Mesenchymal TransitionFemaleGene Expression Regulation, NeoplasticHumansMiceMice, Inbred BALB CMice, NudeMicroRNAsMiddle AgedCBX5 protein, humanChromobox Protein Homolog 5MicroRNAsMIRN98 microRNA, humanPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktcell proliferationcervical cancerMicroRNA-98-5pPI3K/Akt

Identifiers

PMID34895048
PMCPMC8810110
OpenAlexW4200404003

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.