Evidence map›Paper›PMID 34894977›Full record

ArticleJournal of enzyme inhibition and medicinal chemistry2022

The discovery of a novel series of potential ERRα inverse agonists based on p-nitrobenzenesulfonamide template for triple-negative breast cancer

Zhipei Gao, Tianxiao Wang, Rui Li, Yongli Du, Han Lv, Liudi Zhang, Haifei Chen, Xiaojin Shi, Qunyi Li, Jingkang Shen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of enzyme inhibition and medicinal chemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.0field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Novel Withanolides fromMolecules (Basel, Switzerland) · 2024
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Zhipei GaoSchool of Chemistry and Chemical Engineering, Qilu University of Technology (Shandong Academy of Sciences), Jinan, P. R. China.
Tianxiao WangDepartment of Pharmacy, Huashan Hospital, Fudan University, Shanghai, P. R. China.
Rui LiSchool of Chemistry and Chemical Engineering, Qilu University of Technology (Shandong Academy of Sciences), Jinan, P. R. China.
Yongli DuSchool of Chemistry and Chemical Engineering, Qilu University of Technology (Shandong Academy of Sciences), Jinan, P. R. China.
Han LvSchool of Chemistry and Chemical Engineering, Qilu University of Technology (Shandong Academy of Sciences), Jinan, P. R. China.
Liudi ZhangDepartment of Pharmacy, Huashan Hospital, Fudan University, Shanghai, P. R. China.
Haifei ChenDepartment of Pharmacy, Huashan Hospital, Fudan University, Shanghai, P. R. China.
Xiaojin ShiDepartment of Pharmacy, Huashan Hospital, Fudan University, Shanghai, P. R. China.
Qunyi LiDepartment of Pharmacy, Huashan Hospital, Fudan University, Shanghai, P. R. China.
Jingkang ShenState Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, P. R. China.
Huashan Hospital · CNShandong Academy of Sciences · CNChinese Academy of Sciences · CNFudan University · CNQilu University of Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oestrogen related receptor α participated in the regulation of oxidative metabolism and mitochondrial biogenesis, and was overexpressed in many cancers including triple-negative breast cancer. A set of new ERRα inverse agonists based on p-nitrobenzenesulfonamide template were discovered and compound

Indexed as

Drug DiscoveryAntineoplastic AgentsCell Line, TumorCell ProliferationDose-Response Relationship, DrugDrug Screening Assays, AntitumorERRalpha Estrogen-Related ReceptorFemaleHumansMolecular Docking SimulationMolecular StructureNitrobenzenesReceptors, EstrogenStructure-Activity RelationshipSulfonamidesTriple Negative Breast NeoplasmsAntineoplastic AgentsERRalpha Estrogen-Related ReceptornitrobenzeneNitrobenzenesReceptors, EstrogenSulfonamidesERRαinverse agonistp-NitrobenzenesulfonamideTNBC

Identifiers

PMID34894977
PMCPMC8667933
OpenAlexW4200328683

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.