Evidence map›Paper›PMID 34894967›Full record

ArticleJournal of enzyme inhibition and medicinal chemistry2022

Synthesis and biological evaluation of halogenated phenoxychalcones and their corresponding pyrazolines as cytotoxic agents in human breast cancer.

Peter A Halim, Rasha A Hassan, Khaled O Mohamed, Soha O Hassanin, Mona G Khalil, Amr M Abdou, Eman O Osman

Open access · goldAbstract read
In one paragraph

Article in Journal of enzyme inhibition and medicinal chemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Novel pyrazolo[3,4-RSC medicinal chemistry · 2023
    Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Peter A HalimPharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
Rasha A HassanPharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
Khaled O MohamedPharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
Soha O HassaninBiochemistry Department, Faculty of Pharmacy, Modern University for Technology and Information, Cairo, Egypt.
Mona G KhalilPharmacology and Toxicology Department, Faculty of Pharmacy, Modern University for Technology and Information, Cairo, Egypt.
Amr M AbdouDepartment of Microbiology and Immunology, National Research Centre, Dokki, Egypt.
Eman O OsmanPharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
Cairo University · EGModern University for Information and Technology · EGNational Research Centre · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Novel halogenated phenoxychalcones

Indexed as

Antineoplastic AgentsApoptosisBreast NeoplasmsCell ProliferationChalconesCytotoxinsDose-Response Relationship, DrugDrug Screening Assays, AntitumorFemaleHalogenationHumansMCF-7 CellsMolecular Docking SimulationMolecular StructurePyrazolesStructure-Activity RelationshipAntineoplastic AgentsChalconesCytotoxinsPyrazolesbreast cancercell cycle profilediaryl etherHalogenated chalconesp38 MAPKpyrazolineROS

Identifiers

PMID34894967
PMCPMC8667918
OpenAlexW4200585442

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.