Evidence map›Paper›PMID 34894953›Full record

ArticleJournal of enzyme inhibition and medicinal chemistry2022

New 1,2,4-oxadiazole derivatives with positive mGlu

Anna Stankiewicz, Katarzyna Kaczorowska, Ryszard Bugno, Aneta Kozioł, Maria H Paluchowska, Grzegorz Burnat, Barbara Chruścicka, Paulina Chorobik, Piotr Brański, Joanna M Wierońska and 3 more

Abstract read
In one paragraph

Article in Journal of enzyme inhibition and medicinal chemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Update on mGlu4 modulator patents: 2017 to present.Expert opinion on therapeutic patents · 2025
    Review
  2. Room Temperature Synthesis of Bioactive 1,2,4-Oxadiazoles.International journal of molecular sciences · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Anna StankiewiczDepartment of Medicinal Chemistry, Maj Institute of Pharmacology, Polish Academy of Sciences, Kraków, Poland.
Katarzyna KaczorowskaDepartment of Medicinal Chemistry, Maj Institute of Pharmacology, Polish Academy of Sciences, Kraków, Poland.ORCID 0000-0001-9221-947X
Ryszard BugnoDepartment of Medicinal Chemistry, Maj Institute of Pharmacology, Polish Academy of Sciences, Kraków, Poland.ORCID 0000-0003-3741-674X
Aneta KoziołDepartment of Medicinal Chemistry, Maj Institute of Pharmacology, Polish Academy of Sciences, Kraków, Poland.
Maria H PaluchowskaDepartment of Medicinal Chemistry, Maj Institute of Pharmacology, Polish Academy of Sciences, Kraków, Poland.ORCID 0000-0001-9843-2298
Grzegorz BurnatDepartment of Neurobiology, Maj Institute of Pharmacology, Polish Academy of Sciences, Kraków, Poland.ORCID 0000-0002-2300-0850
Barbara ChruścickaDepartment of Neurobiology, Maj Institute of Pharmacology, Polish Academy of Sciences, Kraków, Poland.ORCID 0000-0003-0189-3712
Paulina ChorobikDepartment of Neurobiology, Maj Institute of Pharmacology, Polish Academy of Sciences, Kraków, Poland.ORCID 0000-0002-3711-1594
Piotr BrańskiDepartment of Neurobiology, Maj Institute of Pharmacology, Polish Academy of Sciences, Kraków, Poland.ORCID 0000-0001-6126-0269
Joanna M WierońskaDepartment of Neurobiology, Maj Institute of Pharmacology, Polish Academy of Sciences, Kraków, Poland.
Beata DuszyńskaDepartment of Medicinal Chemistry, Maj Institute of Pharmacology, Polish Academy of Sciences, Kraków, Poland.ORCID 0000-0002-1487-3406
Andrzej PilcDepartment of Neurobiology, Maj Institute of Pharmacology, Polish Academy of Sciences, Kraków, Poland.ORCID 0000-0002-4045-0597
Andrzej J BojarskiDepartment of Medicinal Chemistry, Maj Institute of Pharmacology, Polish Academy of Sciences, Kraków, Poland.ORCID 0000-0003-1417-6333

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Considering the allosteric regulation of mGlu receptors for potential therapeutic applications, we developed a group of 1,2,4-oxadiazole derivatives that displayed mGlu

Indexed as

Allosteric RegulationAnimalsAntipsychotic AgentsDose-Response Relationship, DrugMiceMolecular StructureOxadiazolesReceptors, Metabotropic GlutamateStructure-Activity RelationshipAntipsychotic Agentsmetabotropic glutamate receptor 4OxadiazolesReceptors, Metabotropic Glutamate1,2,4-oxadiazolesantipsychotic propertiesanxiolyticsMetabotropic glutamate receptor 4 (mGlu4 receptor)positive allosteric modulator (PAM)

Identifiers

PMID34894953
PMCPMC8667925

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.