ReviewBioconjugate chemistry2022
Gold Nanoclusters: Imaging, Therapy, and Theranostic Roles in Biomedical Applications.
Review in Bioconjugate chemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
49 citing papers in PubMed, 182 citations in OpenAlex.
- Role of nanoclusters in the design and development of novel strategies for diagnosis and treatment of infectious diseases.Nanoscale advances · 2026Review
- Advances in Optical and Fluorescence Imaging for Surgical Management of Thyroid Cancer.Cancers · 2026Review
- Stabilization of Ligand-Free Small Gold Nanocluster Within a Metal-Organic Framework for Enhanced Hydrogen Evolution and Horseradish Peroxidase-Mimicking Catalysis in Aqueous Media.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- Ultrasmall Ligand-Protected AgACS nano · 2026Article
- Synergistic Effects in Matrix-Embedded Alloy Nanoclusters: Advanced Type-I Photosensitizers for Theranostics.ACS applied materials & interfaces · 2026Article
- Manipulating the Intersystem Crossing Process in Atomically Precise Gold Nanoclusters.The journal of physical chemistry letters · 2025Review
- Co-Reactant Engineering for Au Nanocluster Electrochemiluminescence.Molecules (Basel, Switzerland) · 2025Review
- Multifunctional gold nanoclusters as next-generation theranostic platforms for disease management.International journal of pharmaceutics: X · 2025Review
- Engineered Plasmonic and Fluorescent Nanomaterials for Biosensing, Motion, Imaging, and Therapeutic Applications.Advanced materials (Deerfield Beach, Fla.) · 2025Review
- Atomically Precise Metal Nanoclusters for Bioimaging and Therapy: Progress and Perspectives.JACS Au · 2025Review
- Predicting the Optical Properties of Gold Nanoclusters Using Machine Learning Approach.ACS omega · 2025Article
- Anchoring Gold Nanoparticles on Functionalized Halloysite Nanotubes: Density Functional Theory and Experimental Studies.The journal of physical chemistry. C, Nanomaterials and interfaces · 2025Article
- Synthesis, characterization of ultrasmall gold nanocluster conjugated with Gemcitabine for anticancer activity.Medical oncology (Northwood, London, England) · 2025Article
- Molecular Gold Nanoclusters for Advanced NIR-II Bioimaging and Therapy.Chemical reviews · 2025Review
- Promising biomedical applications using superparamagnetic nanoparticles.European journal of medical research · 2025Review
- Red-light Emitting Orthogonally Trireactive Gold Nanoclusters for the Synthesis of Multifunctionalized Nanomaterials.Small (Weinheim an der Bergstrasse, Germany) · 2025Article
- Atomically-precise AuJournal of nanobiotechnology · 2025Article
- Long-Term Safety Evaluation of Fluorescent Gold Nanoclusters Conjugated with α-Lipoic Acid: Insights from a Six-Month In Vivo Study.Journal of functional biomaterials · 2025Article
- Advances in nanotechnology for targeting cancer-associated fibroblasts: A review of multi-strategy drug delivery and preclinical insights.APL bioengineering · 2025Review
- Advancements and future directions of iron oxide nanoparticles in cancer therapy.Contemporary oncology (Poznan, Poland) · 2025Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
For the past two decades, atomic gold nanoclusters (AuNCs, ultrasmall clusters of several to 100 gold atoms, having a total diameter of <2 nm) have emerged as promising agents in the diagnosis and treatment of cancer. Owing to their small size, significant quantization occurs to their conduction band, which leads to emergent photonic properties and the disappearance of the plasmonic responses observed in larger gold nanoparticles. For example, AuNCs exhibit native luminescent properties, which have been well-explored in the literature. Using proteins, peptides, or other biomolecules as structural scaffolds or capping ligands, required for the stabilization of AuNCs, improves their biocompatibility, while retaining their distinct optical properties. This paved the way for the use of AuNCs in fluorescent bioimaging, which later developed into multimodal imaging combined with computer tomography and magnetic resonance imaging as examples. The development of AuNC-based systems for diagnostic applications in cancer treatment was then made possible by employing active or passive tumor targeting strategies. Finally, the potential therapeutic applications of AuNCs are extensive, having been used as light-activated and radiotherapy agents, as well as nanocarriers for chemotherapeutic drugs, which can be bound to the capping ligand or directly to the AuNCs via different mechanisms. In this review, we present an overview of the diverse biomedical applications of AuNCs in terms of cancer imaging, therapy, and combinations thereof, as well as highlighting some additional applications relevant to biomedical research.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.