Evidence map›Paper›PMID 34894521›Full record

ArticleJournal of psychiatric research2022

One-year mental health outcomes in a cohort of COVID-19 survivors.

Mario Gennaro Mazza, Mariagrazia Palladini, Rebecca De Lorenzo, Beatrice Bravi, Sara Poletti, Roberto Furlan, Fabio Ciceri, COVID-19 BioB Outpatient Clinic Study group, Patrizia Rovere-Querini, Francesco Benedetti

2 registry-linked trialsOpen access · greenAbstract read
In one paragraph

Article in Journal of psychiatric research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 54 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed, 6 pooled it
9.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06945627 active not recruitingnot on this mapstarted 2024, after this paper: background citation

Profiling Vulnerability and Resilience for Mental Illness Following Viral Infections: Translating Epidemiology to Deep-phenotyping

TypeobservationalSponsorSara PolettiRan2024 to 2027Enrolled408,551ConditionsSevere Mental Illness, Inflammation, Viral Infections, Mood DisordersArmsThis research doesn't involve any kind of intervention on the study participants
NCT07453420 active not recruitingnot on this mapstarted 2024, after this paper: background citation

Profiling Vulnerability and Resilience for Mental Illness Following Viral Infections: Translating Epidemiology to Deep-phenotyping.

TypeobservationalSponsorShalvata Mental Health CenterRan2024 to 2027Enrolled100,000ConditionsAnxiety, Depression - Major Depressive Disorder, Bipolar, Schizophenia Disorder
3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 6 syntheses or guidelines pooled it, 100 citations in OpenAlex.

  1. Global prevalence of post-COVID-19 condition: a systematic review and meta-analysis of prospective evidence.Health promotion and chronic disease prevention in Canada : research, policy and practice · 2025
    Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Long-Term Consequences of COVID-19 at 6 Months and Above: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2022
    Pooled it
  6. Pooled it
  7. Article
  8. Article
  9. Article
  10. Observational
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Social determinants of health and COVID-19 recovery after inpatient rehabilitation.PM & R : the journal of injury, function, and rehabilitation · 2024
    Article
  18. Article
  19. Portrait of mental health identified by people with the post-covid syndrome.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2024
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Mario Gennaro MazzaPsychiatry & Clinical Psychobiology, Division of Neuroscience, IRCCS Scientific Institute Ospedale, San Raffaele, Milano, Italy; Vita-Salute San Raffaele University, Milano, Italy. Electronic address: mazza.mariogennaro@hsr.it.
Mariagrazia PalladiniPsychiatry & Clinical Psychobiology, Division of Neuroscience, IRCCS Scientific Institute Ospedale, San Raffaele, Milano, Italy.
Rebecca De LorenzoVita-Salute San Raffaele University, Milano, Italy; Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Beatrice BraviPsychiatry & Clinical Psychobiology, Division of Neuroscience, IRCCS Scientific Institute Ospedale, San Raffaele, Milano, Italy.
Sara PolettiPsychiatry & Clinical Psychobiology, Division of Neuroscience, IRCCS Scientific Institute Ospedale, San Raffaele, Milano, Italy; Vita-Salute San Raffaele University, Milano, Italy.
Roberto FurlanVita-Salute San Raffaele University, Milano, Italy; Clinical Neuroimmunology, Division of Neuroscience, IRCCS Scientific Institute Ospedale San Raffaele, Milano, Italy.
Fabio CiceriVita-Salute San Raffaele University, Milano, Italy; Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy.
COVID-19 BioB Outpatient Clinic Study group
Patrizia Rovere-QueriniVita-Salute San Raffaele University, Milano, Italy; Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Francesco BenedettiPsychiatry & Clinical Psychobiology, Division of Neuroscience, IRCCS Scientific Institute Ospedale, San Raffaele, Milano, Italy; Vita-Salute San Raffaele University, Milano, Italy.
Vita-Salute San Raffaele University · ITIRCCS Ospedale San Raffaele · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

COVID-19 survivors are at increased risk of persistent psychopathology after the infection. Despite long-term sequelae are an increasing concern, long-term neuropsychiatric consequences remain largely unclear. This cohort study aimed at investigating the psychopathological impact of COVID-19 in Italy one year after infection, outlining the trajectory of symptomatology at one, six-, and twelve-months follow-up. We evaluated 402, 216, and 192 COVID-19 survivors respectively at one, six, and 12 months. A subgroup of 95 patients was evaluated longitudinally both at one, six, and 12 months. Validated self-report questionnaires were administered to assess depression, fatigue, anxiety, and post-traumatic distress. Socio-demographics and setting of care information were gathered for each participant. At six and twelve months, respectively 94 (44%) and 86 (45%) patients self-rated in the clinical range in at least one psychopathological dimension. Pathological fatigue at twelve months was detected in 63 patients (33%). Considering the longitudinal cohort an interaction effect of sex and time was observed for depression (F = 8.63, p < 0.001) and anxiety (F = 5.42, p = 0.005) with males showing a significant increasing trend of symptoms, whereas an opposite course was observed in females. High prevalence of psychiatric sequelae six and 12 months after COVID-19 was reported for the first time. These findings confirm the need to provide integrated multidisciplinary services to properly address long-lasting mental health sequelae of COVID-19 and to treat them with the aim of reducing the disease burden and related years of life lived with disability.

Indexed as

AnxietyCOVID-19DepressionFatigueMental healthSARS-CoV-2

Identifiers

PMID34894521
PMCPMC8607816
OpenAlexW3216705068

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.