Evidence map›Paper›PMID 34894416›Full record

ArticleBrain and behavior2022

Association of serum cholesterol with Parkinson's disease in a cohort of statin-free individuals.

Yukai Lv, Bo Xu, Xuejuan Zhang, Chunhuan Chen, Yan Gao, Ning Li

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain and behavior, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. Update: Protective and risk factors for Parkinson disease.Parkinsonism & related disorders · 2024
    Review
  6. Review
  7. Review
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Yukai LvDepartment of Pediatrics, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Bo XuDepartment of Thoracic Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Xuejuan ZhangDepartment of Radiology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Chunhuan ChenDepartment of Anaesthesiology, Jinshan Hospital, Fudan University, Shanghai, China.
Yan GaoDepartment of Neurology, Affiliated Hospital of Hebei University, Baoding, China.
Ning LiDepartment of Neurology, Affiliated Hospital of Hebei University, Baoding, China.
Affiliated Hospital of Hebei University · CNThe First Affiliated Hospital, Sun Yat-sen University · CNJinshan Hospital of Fudan University · CNSun Yat-sen University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe role of serum cholesterol in the pathogenesis of Parkinson's disease (PD) remains unclear. The objective of this study was to assess the association between serum cholesterol and PD in a cohort of statin-free newly diagnosed PD patients.

methodsThis retrospective study used fasting lipid profiles obtained from 672 consecutive statin-free newly diagnosed PD individuals and 540 controls. These PD individuals were identified from three medical institutions during 2017-2021, and the controls were identified from three physical examination centers during the same time period. Logistic regressions were used to estimate odds ratios (ORs) and 95% confidence intervals (CIs), with adjustment of age, sex, and tobacco use history.

resultsAmong 672 PD individuals, 112 were excluded in accordance with the current criteria, leaving 560 PD patients. The multivariate binary logistic regression analysis showed that LDL-C was the only variable contributing to the occurrence of PD (OR 1.39, 95% CI: 1.07-2.31, p < .001) after adjusting for age, sex, and tobacco use history; this association persisted following further adjustment for TC and HDL-C. In the subgroup analysis of the adjusted results of LDL-C after correcting for TC and HDL-C, lower LDL-C was associated with a higher risk of PD.

conclusionAmong selected populations of statin-free newly diagnosed PD individuals, low LDL-C might be associated with the occurrence of PD.

Indexed as

Hydroxymethylglutaryl-CoA Reductase InhibitorsParkinson DiseaseCholesterol, LDLCohort StudiesHumansRetrospective StudiesRisk FactorsCholesterol, LDLHydroxymethylglutaryl-CoA Reductase Inhibitorsassociationlow-density lipoprotein statinParkinson's diseaseserum cholesterolstatin

Identifiers

PMID34894416
PMCPMC8785640
OpenAlexW4200154197

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.