Evidence map›Paper›PMID 34894346›Full record

ReviewClinical pharmacokinetics2022

Cladribine as a Potential Object of Nucleoside Transporter-Based Drug Interactions.

Robert Hermann, Peter Krajcsi, Markus Fluck, Annick Seithel-Keuth, Afrim Bytyqi, Andrew Galazka, Alain Munafo

Open access · hybridAbstract readReview
In one paragraph

Review in Clinical pharmacokinetics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. CNS Resident Innate Immune Cells: Guardians of CNS Homeostasis.International journal of molecular sciences · 2024
    Review
  4. Review
  5. Article
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 3 countries.

Robert HermannClinical Research Appliance (cr.appliance), Heinrich-Vingerhut-Weg 3, 63571, Gelnhausen, Germany. robert.hermann@cr-appliance.com.ORCID 0000-0002-1326-5943
Peter KrajcsiHabilitas Kft, Budapest, Hungary.
Markus FluckMerck Healthcare KGaA, Darmstadt, Germany.
Annick Seithel-KeuthMerck Healthcare KGaA, Darmstadt, Germany.
Afrim BytyqiMerck Healthcare KGaA, Darmstadt, Germany.
Andrew GalazkaAn Affiliate of Merck KGaA, Ares Trading SA, Eysins, Switzerland.
Alain MunafoAn Affiliate of Merck KGaA, Merck Institute of Pharmacometrics, Lausanne, Switzerland.
Merck (Germany) · DEMerck Serono (Switzerland) · CHMine Safety Appliances (United States) · US

Funding

merck kgaa CrossRef Funder ID: 10.13039/100009945
6 · The paper itself

Abstract

Cladribine is a nucleoside analog that is phosphorylated in its target cells (B and T-lymphocytes) to its active triphosphate form (2-chlorodeoxyadenosine triphosphate). Cladribine tablets 10 mg (Mavenclad

Indexed as

CladribineNucleoside Transport ProteinsATP-Binding Cassette TransportersATP Binding Cassette Transporter, Subfamily G, Member 2Drug InteractionsEquilibrative Nucleoside Transporter 1HumansMembrane Transport ProteinsNeoplasm ProteinsATP-Binding Cassette TransportersATP Binding Cassette Transporter, Subfamily G, Member 2CladribineEquilibrative Nucleoside Transporter 1Membrane Transport ProteinsNeoplasm ProteinsNucleoside Transport Proteins

Identifiers

PMID34894346
PMCPMC8813788
OpenAlexW4200427579

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.