Evidence map›Paper›PMID 34894332›Full record

ReviewThe Journal of the Egyptian Public Health Association2021

The protective role of vitamin C in the management of COVID-19: A Review.

Mohammad Sarowar Uddin, Md Shalahuddin Millat, Prodip Kumar Baral, Mahmuda Ferdous, Md Giash Uddin, Md Shahid Sarwar, Mohammad Safiqul Islam

Open access · diamondAbstract readReview
In one paragraph

Review in The Journal of the Egyptian Public Health Association, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 22 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Mohammad Sarowar UddinDepartment of Pharmacy, Noakhali Science & Technology University, Noakhali, 3814, Bangladesh. pharmasarowar@gmail.com.ORCID http://orcid.org/0000-0002-9460-0300
Md Shalahuddin MillatDepartment of Pharmacy, Noakhali Science & Technology University, Noakhali, 3814, Bangladesh.
Prodip Kumar BaralDepartment of Pharmacy, Noakhali Science & Technology University, Noakhali, 3814, Bangladesh.
Mahmuda FerdousDepartment of Pharmacy, Noakhali Science & Technology University, Noakhali, 3814, Bangladesh.
Md Giash UddinDepartment of Pharmacy, University of Chittagong, Chittagong, 4331, Bangladesh.
Md Shahid SarwarDepartment of Pharmacy, Noakhali Science & Technology University, Noakhali, 3814, Bangladesh.
Mohammad Safiqul IslamDepartment of Pharmacy, Noakhali Science & Technology University, Noakhali, 3814, Bangladesh.
Noakhali Science and Technology University · BDUniversity of Chittagong · BD

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe outbreak of coronavirus infectious disease-2019 (COVID-19) is globally deemed a significant threat to human life. Researchers are searching for prevention strategies, mitigation interventions, and potential therapeutics that may reduce the infection's severity. One such means that is highly being talked in online and in social media is vitamin C. MAIN TEXT: Vitamin C is a robust antioxidant that boosts the immune system of the human body. It helps in normal neutrophil function, scavenging of oxidative species, regeneration of vitamin E, modulation of signaling pathways, activation of pro-inflammatory transcription factors, activation of the signaling cascade, regulation of inflammatory mediators, and phagocytosis and increases neutrophil motility to the site of infection. All of these immunological functions are required for the prevention of COVID-19 infection.

conclusionConsidering the role of vitamin C, it would be imperative to administrate vitamin C for the management of severe COVID-19. However, there is no specific clinical data available to confirm the use of vitamin C in the current pandemic.

Indexed as

COVID-19ImmunityPathogenesis of COVID-19Vitamin C

Identifiers

PMID34894332
PMCPMC8665316
OpenAlexW4200082495

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.