ArticlePlant physiology2022
bHLH11 inhibits bHLH IVc proteins by recruiting the TOPLESS/TOPLESS-RELATED corepressors.
Article in Plant physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- OsbHLH064, an IVb bHLH Transcription Factor, Regulates Iron Homeostasis and Enhances Grain Fe Accumulation in Rice.Plant biotechnology journal · 2026Article
- Iron status modulates cadmium tolerance: mechanistic insights fromFrontiers in plant science · 2026Article
- OsbHLH062 regulates iron homeostasis by inhibiting iron deficiency responses in rice.aBIOTECH · 2025Article
- Shedding light on iron nutrition: exploring intersections of transcription factor cascades in light and iron deficiency signaling.Journal of experimental botany · 2025Review
- Evolution of ANT family and regulation of lint percentage by the GhAIL6-GhTPL1 module.Frontiers in plant science · 2025Article
- The bHLH Transcription Factor PhbHLH121 Regulates Response to Iron Deficiency inPlants (Basel, Switzerland) · 2024Article
- Insights into the genetic architecture of the reciprocal interspecific hybrids derived fromMolecular breeding : new strategies in plant improvement · 2024Article
- AlfalfaFrontiers in plant science · 2024Article
- The Molecular Mechanism ofPlants (Basel, Switzerland) · 2023Article
- The transcription factor POPEYE negatively regulates the expression of bHLH Ib genes to maintain iron homeostasis.Journal of experimental botany · 2023Article
- Iron Nutrition in Plants: Towards a New Paradigm?Plants (Basel, Switzerland) · 2023Review
- Iron sensing in plants.Frontiers in plant science · 2023Review
- The bHLH Transcription Factor OsbHLH057 Regulates Iron Homeostasis in Rice.International journal of molecular sciences · 2022Article
- Iron uptake, signaling, and sensing in plants.Plant communications · 2022Review
- The Iron Deficiency-Regulated Small Protein Effector FEP3/IRON MAN1 Modulates Interaction of BRUTUS-LIKE1 With bHLH Subgroup IVc and POPEYE Transcription Factors.Frontiers in plant science · 2022Article
- Impact of Iron Deficiency on the Arabidopsis thaliana Phloem Sap Proteome, a Key Role for bHLH121.Physiologia plantarumArticle
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7 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Iron (Fe) homeostasis is essential for plant growth and development. Many transcription factors (TFs) play pivotal roles in the maintenance of Fe homeostasis. bHLH11 is a negative TF that regulates Fe homeostasis. However, the underlying molecular mechanism remains elusive. Here, we generated two loss-of-function bhlh11 mutants in Arabidopsis (Arabidopsis thaliana), which display enhanced sensitivity to excess Fe, increased Fe accumulation, and elevated expression of Fe deficiency responsive genes. Levels of bHLH11 protein, localized in both the cytoplasm and nucleus, decreased in response to Fe deficiency. Co-expression assays indicated that bHLH IVc TFs (bHLH34, bHLH104, bHLH105, and bHLH115) facilitate the nuclear accumulation of bHLH11. Further analysis indicated that bHLH11 represses the transactivity of bHLH IVc TFs toward bHLH Ib genes (bHLH38, bHLH39, bHLH100, and bHLH101). The two ethylene response factor-associated amphiphilic repression motifs of bHLH11 provided the repression function by recruiting the TOPLESS/TOPLESS-RELATED (TPL/TPRs) corepressors. Correspondingly, the expression of Fe uptake genes increased in the tpr1 tpr4 tpl mutant. Moreover, genetic analysis revealed that bHLH11 has functions independent of FER-LIKE IRON DEFICIENCY-INDUCED TRANSCRIPTION FACTOR. This study provides insights into the complicated Fe homeostasis signaling network.
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