ReviewAAPS PharmSciTech2021
Recent Advances in Enhancement of Dissolution and Supersaturation of Poorly Water-Soluble Drug in Amorphous Pharmaceutical Solids: A Review.
Review in AAPS PharmSciTech, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed.
- Colloidal Stability of Amorphous Nanoparticles in Solution: Impact of Stabilizer.Pharmaceutical research · 2026Article
- Development of Amorphous Solid Dispersion to Improve the Dissolution and Antiproliferative Activity of Brazilin.Drug design, development and therapy · 2026Article
- Assessing the Impact of Mesoporous, Co-Amorphous, and Polymer-Based Systems on Cefdinir's Dissolution and Stability Via Predictive Modeling.British journal of biomedical science · 2026Article
- Two Drug-Drug Co-Amorphous Systems of Curcumin and Berberine Hydrochloride/Palmatine Hydrochloride with Improved Physicochemical Properties and Multifunctional Activities.Pharmaceutics · 2025Article
- Crystallizing the Uncrystallizable: Insights from Extensive Screening of PROTACs.Journal of the American Chemical Society · 2025Article
- Development and Preclinical Evaluation of Fixed-Dose Capsules Containing Nicergoline, Piracetam, and Hawthorn Extract for Sensorineural Hearing Loss.Pharmaceutics · 2025Article
- Enhanced solubility and bioavailability of coenzyme Q10 via co-amorphous system using stevioside.NPJ science of food · 2025Article
- Mechanistic Insights into Amorphous Solid Dispersions: Bridging Theory and Practice in Drug Delivery.Pharmaceutical research · 2025Review
- Article
- Sweeteners Show a Plasticizing Effect on PVP K30-A Solution for the Hot-Melt Extrusion of Fixed-Dose Amorphous Curcumin-Hesperetin Solid Dispersions.Pharmaceutics · 2024Article
- Implications of Low-concentration Polymer on the Physical Stability of Glassy Griseofulvin: Role of the Segmental Mobility.AAPS PharmSciTech · 2024Article
- The Fabrication, Drug Loading, and Release Behavior of Porous Mannitol.Molecules (Basel, Switzerland) · 2024Article
- Statistical analysis of the storage time of finished product infusion.The Journal of international medical research · 2024Article
- Development of an Image-based Method for Tablet Microstructure Description and Its Correlation with API Release Rate.AAPS PharmSciTech · 2023Article
- Mesoporous Drug Delivery System: From Physical Properties of Drug in Solid State to Controlled Release.Molecules (Basel, Switzerland) · 2023Review
- Introduction to Pharmaceutical Co-amorphous Systems Using a Green Co-milling Technique.Journal of chemical education · 2023Article
- Cyclosporine A-Loaded Ternary Solid Dispersion Prepared with Fine Droplet Drying Process for Improvement of Storage Stability and Oral Bioavailability.Pharmaceutics · 2023Article
- Co-amorphous Drug Delivery Systems: a Review of Physical Stability, In Vitro and In Vivo Performance.AAPS PharmSciTech · 2022Review
- Amorphous Solid Dispersions: Role of the Polymer and Its Importance in Physical Stability and In Vitro Performance.Pharmaceutics · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Amorphization is one of the most effective pharmaceutical approaches to enhance the dissolution and oral bioavailability of poorly water-soluble drugs. In recent years, amorphous formulations have been experiencing rapid development both in theoretical and practical application. Based on using different types of stabilizing agents, amorphous formulations can be mainly classified as polymer-based amorphous solid dispersion, coamorphous formulation, mesoporous silica-based amorphous formulation, etc. This paper summarizes recent advances in the dissolution and supersaturation of these amorphous formulations. Moreover, we also highlight the roles of stabilizing agents such as polymers, low molecular weight co-formers, and mesoporous silica. Maintaining supersaturation in solution is a key factor for the enhancement of dissolution profile and oral bioavailability, and thus, the strategies and challenges for maintaining supersaturation are also discussed. With an in-depth understanding of the inherent mechanisms of dissolution behaviors, the design of amorphous pharmaceutical formulations will become more scientific and reasonable, leading to vigorous development of commercial amorphous drug products.
Indexed as
Identifiers
34893936What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.