ArticleThe Plant cell2022
The Chlamydomonas bZIP transcription factor BLZ8 confers oxidative stress tolerance by inducing the carbon-concentrating mechanism.
Article in The Plant cell, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19 citing papers in PubMed, 53 citations in OpenAlex.
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- The genome of Pleurosigma provides insights into the evolutionary adaptations of pelagic diatoms.DNA research : an international journal for rapid publication of reports on genes and genomes · 2026Article
- Low Carbon Inducible2/Fatty Acid Desaturase4 locus in C. reinhardtii directs plastid peroxidase location and trans fatty acid production.Plant physiology · 2025Article
- Uridine diphosphate glucose confers oxidative stress tolerance in microalgae.BMC plant biology · 2025Article
- Mechanism of Transcription Factor ChbZIP1 Enhanced Alkaline Stress Tolerance inInternational journal of molecular sciences · 2025Article
- AlgaeOrtho, a bioinformatics tool for processing ortholog inference results in algae.Frontiers in microbiology · 2025Article
- Highly Active Carbonic Anhydrase of the Thylakoid Lumen ofPlants (Basel, Switzerland) · 2024Article
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- Harnessing genetic engineering to drive economic bioproduct production in algae.Frontiers in bioengineering and biotechnology · 2024Review
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- UDP-glucose pyrophosphorylase as a target for regulating carbon flux distribution and antioxidant capacity in Phaeodactylum tricornutum.Communications biology · 2023Article
- Widening the landscape of transcriptional regulation of green algal photoprotection.Nature communications · 2023Article
- Double DAP-seq uncovered synergistic DNA binding of interacting bZIP transcription factors.Nature communications · 2023Article
- A pyrenoid-localized protein SAGA1 is necessary for CaPhotosynthesis research · 2023Article
- Transcriptional Regulatory Network of Plant Cadmium Stress Response.International journal of molecular sciences · 2023Review
- Identification and Analysis of bZIP Family Genes inFrontiers in plant science · 2022Article
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Authors and funding
11 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Photosynthetic organisms are exposed to various environmental sources of oxidative stress. Land plants have diverse mechanisms to withstand oxidative stress, but how microalgae do so remains unclear. Here, we characterized the Chlamydomonas reinhardtii basic leucine zipper (bZIP) transcription factor BLZ8, which is highly induced by oxidative stress. Oxidative stress tolerance increased with increasing BLZ8 expression levels. BLZ8 regulated the expression of genes likely involved in the carbon-concentrating mechanism (CCM): HIGH-LIGHT ACTIVATED 3 (HLA3), CARBONIC ANHYDRASE 7 (CAH7), and CARBONIC ANHYDRASE 8 (CAH8). BLZ8 expression increased the photosynthetic affinity for inorganic carbon under alkaline stress conditions, suggesting that BLZ8 induces the CCM. BLZ8 expression also increased the photosynthetic linear electron transfer rate, reducing the excitation pressure of the photosynthetic electron transport chain and in turn suppressing reactive oxygen species (ROS) production under oxidative stress conditions. A carbonic anhydrase inhibitor, ethoxzolamide, abolished the enhanced tolerance to alkaline stress conferred by BLZ8 overexpression. BLZ8 directly regulated the expression of the three target genes and required bZIP2 as a dimerization partner in activating CAH8 and HLA3. Our results suggest that a CCM-mediated increase in the CO2 supply for photosynthesis is critical to minimize oxidative damage in microalgae, since slow gas diffusion in aqueous environments limits CO2 availability for photosynthesis, which can trigger ROS formation.
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