ArticlePlant physiology2022
The positive feedback regulatory loop of miR160-Auxin Response Factor 17-HYPONASTIC LEAVES 1 mediates drought tolerance in apple trees.
Article in Plant physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 68 citations in OpenAlex.
- An integrative multi-omics analysis of histone modifications and DNA methylation reveals the epigenomic landscape in apple under drought stress.Plant biotechnology journal · 2025Article
- Non-coding RNAs in plant stress responses: molecular insights and agricultural applications.Plant biotechnology journal · 2025Review
- Engineering saline-alkali-tolerant apple rootstocks by overexpressingMolecular breeding : new strategies in plant improvement · 2025Article
- The Auxin Response FactorPlants (Basel, Switzerland) · 2025Article
- Auxin Orchestrates Germ Cell Specification inInternational journal of molecular sciences · 2025Review
- Genome-wide identification and functional analysis of the ARF gene family in tetraploid potato reveal its potential role in anthocyanin biosynthesis.BMC plant biology · 2025Article
- Article
- Exploring Drought Resistance Genes from the Roots of the Wheat Cultivar Yunhan1818.International journal of molecular sciences · 2024Article
- Characterization and expression analysis of the B3 gene family during seed development in Akebia trifoliata.BMC genomics · 2024Article
- Analysis of the miR482 Gene Family in Plants.Genes · 2024Article
- ThePhysiology and molecular biology of plants : an international journal of functional plant biology · 2024Article
- Surviving a Double-Edged Sword: Response of Horticultural Crops to Multiple Abiotic Stressors.International journal of molecular sciences · 2024Review
- The chromatin remodeller MdRAD5B enhances drought tolerance by coupling MdLHP1-mediated H3K27me3 in apple.Plant biotechnology journal · 2024Article
- Whole-Transcriptome Sequencing Reveals the Global Molecular Responses and NAC Transcription Factors Involved in Drought Stress inAntioxidants (Basel, Switzerland) · 2024Article
- Function identification of miR159a, a positive regulator during poplar resistance to drought stress.Horticulture research · 2023Article
- Effects of PmaIAA27 and PmaARF15 genes on drought stress tolerance in pinus massoniana.BMC plant biology · 2023Article
- The miRNA-mRNA Regulatory Modules ofInternational journal of molecular sciences · 2023Article
- Noncoding RNAs and their roles in regulating the agronomic traits of crops.Fundamental research · 2023Review
- Insights into the molecular mechanisms underlying responses of apple trees to abiotic stresses.Horticulture research · 2023Article
- The RNA-binding protein MdHYL1 modulates cold tolerance and disease resistance in apple.Plant physiology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Drought stress tolerance is a complex trait regulated by multiple factors. Here, we demonstrate that the miRNA160-Auxin Response Factor 17 (ARF17)-HYPONASTIC LEAVES 1 module is crucial for apple (Malus domestica) drought tolerance. Using stable transgenic plants, we found that drought tolerance was improved by higher levels of Mdm-miR160 or MdHYL1 and by decreased levels of MdARF17, whereas reductions in MdHYL1 or increases in MdARF17 led to greater drought sensitivity. Further study revealed that modulation of drought tolerance was achieved through regulation of drought-responsive miRNA levels by MdARF17 and MdHYL1; MdARF17 interacted with MdHYL1 and bound to the promoter of MdHYL1. Genetic analysis further suggested that MdHYL1 is a direct downstream target of MdARF17. Importantly, MdARF17 and MdHYL1 regulated the abundance of Mdm-miR160. In addition, the Mdm-miR160-MdARF17-MdHYL1 module regulated adventitious root development. We also found that Mdm-miR160 can move from the scion to the rootstock in apple and tomato (Solanum lycopersicum), thereby improving root development and drought tolerance of the rootstock. Our study revealed the mechanisms by which the positive feedback loop of Mdm-miR160-MdARF17-MdHYL1 influences apple drought tolerance.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.