ArticleJournal of the National Cancer Institute2022
The Survival Impact of Second Primary Lung Cancer in Patients With Lung Cancer.
Article in Journal of the National Cancer Institute, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- Evaluation of surgical outcomes and prognostic factors of second primary lung cancer based on a systematic review and meta-analysis.BMC surgery · 2023Pooled it
- Lung Cancer Survivorship: Challenges and Care Needs.Cancers · 2026Review
- Real-World Mapping of Multiple Primary Carcinoma Combinations and Survival Outcomes in Shanghai, China: Retrospective Registry-Based Study.JMIR public health and surveillance · 2026Article
- Air pollution and the risk of second primary lung cancer among lung cancer survivors: the prospective UK Biobank cohort study.British journal of cancer · 2026Article
- Impact of prior malignancy on non-small cell lung cancer presentation, management, and survival.Journal of thoracic disease · 2026Article
- Racial/ethnic and geographic differences in second primary cancers in stomach cancer survivors: a comparative study of U.S. and South Korea.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2026Article
- Construction of a novel tool for predicting chronic obstructive pulmonary disease mortality in lung cancer patients.Scientific reports · 2025Article
- Automatic Abstraction of Computed Tomography Imaging Indication Using Natural Language Processing for Evaluation of Surveillance Patterns in Long-Term Lung Cancer Survivors.JCO clinical cancer informatics · 2025Article
- Clinical features and prognostic nomogram development for cancer-specific death in patients with dual primary lung cancer: a population-based study from SEER database.Journal of cardiothoracic surgery · 2025Article
- Racial and ethnic differences in second primary lung cancer risk among lung cancer survivors.JNCI cancer spectrum · 2024Article
- Article
- Construction of a risk prediction model for lung infection after chemotherapy in lung cancer patients based on the machine learning algorithm.Frontiers in oncology · 2024Article
- Characteristics and classification of first primary cancer patients with second primary cancer: a population-based cohort study.Clinical and experimental medicine · 2023Article
- Second Primary Lung Cancer Among Lung Cancer Survivors Who Never Smoked.JAMA network open · 2023Article
- Beyond the Frontline: A Triple-Line Approach of Thoracic Surgeons in Lung Cancer Management-State of the Art.Cancers · 2023Review
- Racial and Ethnic Disparities in Survival Among People With Second Primary Cancer in the US.JAMA network open · 2023Article
- Predictive Model to Guide Brain Magnetic Resonance Imaging Surveillance in Patients With Metastatic Lung Cancer: Impact on Real-World Outcomes.JCO precision oncology · 2022Article
- Impact of primary site on survival in patients with nasopharyngeal carcinoma from 2004 to 2015.Frontiers in surgery · 2022Article
- Postoperative radiotherapy might be a risk factor for second primary lung cancer: A population-based study.Frontiers in oncology · 2022Article
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundLung cancer survivors have a high risk of developing second primary lung cancer (SPLC), but little is known about the survival impact of SPLC diagnosis.
methodsWe analyzed data from 138 969 patients in the Surveillance, Epidemiology, and End Results (SEER), who were surgically treated for initial primary lung cancer (IPLC) in 1988-2013. Each patient was followed from the date of IPLC diagnosis to SPLC diagnosis (for those with SPLC) and last vital status through 2016. We performed multivariable Cox regression to evaluate the association between overall survival and SPLC diagnosis as a time-varying predictor. To investigate potential effect modification, we tested interaction between SPLC and IPLC stage. Using data from the Multiethnic Cohort Study (MEC) (n = 1540 IPLC patients with surgery), we evaluated the survival impact of SPLC by smoking status. All statistical tests were 2-sided.
resultsA total of 12 115 (8.7%) patients developed SPLC in SEER over 700 421 person-years of follow-up. Compared with patients with single primary lung cancer, those with SPLC had statistically significantly reduced overall survival (hazard ratio [HR] = 2.12, 95% confidence interval [CI] = 2.06 to 2.17; P < .001). The effect of SPLC on reduced survival was more pronounced among patients with early stage IPLC vs advanced-stage IPLC (HR = 2.14, 95% CI = 2.08 to 2.20, vs HR = 1.43, 95% CI = 1.21 to 1.70, respectively; Pinteraction < .001). Analysis using MEC data showed that the effect of SPLC on reduced survival was statistically significantly larger among persons who actively smoked at initial diagnosis vs those who formerly or never smoked (HR = 2.31, 95% CI = 1.48 to 3.61, vs HR = 1.41, 95% CI = 0.98 to 2.03, respectively; Pinteraction = .04).
conclusionsSPLC diagnosis is statistically significantly associated with decreased survival in SEER and MEC. Intensive surveillance targeting patients with early stage IPLC and active smoking at IPLC diagnosis may lead to a larger survival benefit.
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