Evidence map›Paper›PMID 34893806›Full record

ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2022

Incidence and Duration of Pharyngeal Chlamydia Among a Cohort of Men Who Have Sex With Men.

Christine M Khosropour, Olusegun O Soge, Matthew R Golden, James P Hughes, Lindley A Barbee

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review: Known, Emerging, and Remerging Pharyngitis Pathogens.The Journal of infectious diseases · 2024
    Review
  8. Article
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Christine M KhosropourDepartment of Epidemiology, University of Washington, Seattle, Washington, USA.ORCID 0000-0002-9743-0829
Olusegun O SogeDepartment of Global Health, University of Washington, Seattle, Washington, USA.
Matthew R GoldenDepartment of Epidemiology, University of Washington, Seattle, Washington, USA.
James P HughesDepartment of Biostatistics, University of Washington, Seattle, Washington, USA.
Lindley A BarbeeDepartment of Medicine, University of Washington, Seattle, Washington, USA.

Funding

University of Washington/Fred Hutch Center for AIDS ResearchP30AI027757 · NIAID · UNIVERSITY OF WASHINGTON · PI Judith Tsui · 1988 to 2026
$104.9M
Transform Dissemination and Implementation Science in CTSA ProgramsUL1TR002319 · NCATS · UNIVERSITY OF WASHINGTON · PI John K. Amory · 2017 to 2026
$100.0M
Characterizing Extragenital Gonorrhea and Chlamydia: Natural History & HIV ImpactK23AI113185 · NIAID · UNIVERSITY OF WASHINGTON · PI BARBEE, LINDLEY · 2014 to 2018
$903k
NCATS NIH HHS UL1 TR002319NIAID NIH HHS K23 AI113185NIAID NIH HHS P30 AI027757
6 · The paper itself

Abstract

backgroundThe prevalence of pharyngeal chlamydia is low, but its incidence and duration are unknown. A high incidence or duration may support the role of pharyngeal chlamydia in sustaining chlamydia transmission.

methodsFrom March 2016 to December 2018, we enrolled men who have sex with men (MSM) in a 48-week cohort study in Seattle, Washington. Participants self-collected pharyngeal specimens weekly. We tested specimens using nucleic acid amplification testing at the conclusion of the study. In primary analyses, we defined incident pharyngeal chlamydia as >2 consecutive weeks of a positive pharyngeal specimen. In sensitivity analyses, we defined incident chlamydia as >1 week of a positive specimen. We estimated duration of pharyngeal chlamydia, censoring at loss to follow-up, receipt of antibiotics, or end of study.

resultsA total of 140 participants contributed 70.5 person-years (PY); 1.4% had pharyngeal chlamydia at enrollment. In primary analyses, there were 8 pharyngeal chlamydia cases among 6 MSM (incidence = 11.4 per 100 PY; 95% confidence interval [CI]: 6.0-21.9). In sensitivity analysis, there were 19 cases among 16 MSM (incidence = 27.1 per 100 PY; 95% CI: 18.5-39.8). The median duration was 6.0 weeks (95% CI: 2.0-undefined) in primary analysis and 2.0 weeks (95% CI: 1.1-6.0) in sensitivity analysis. Duration was shorter for those with a history of chlamydia compared with those without (3.6 vs 8.7 weeks; P = .02).

conclusionsPharyngeal chlamydia has a low incidence and duration relative to other extragenital sexually transmitted infections. Its contribution to population-level transmission remains unclear.

Indexed as

Chlamydia InfectionsGonorrheaNucleic AcidsSexual and Gender MinoritiesAnti-Bacterial AgentsChlamydia trachomatisCohort StudiesHomosexuality, MaleHumansIncidenceMaleNeisseria gonorrhoeaePrevalenceAnti-Bacterial AgentsNucleic Acidsextragenitalmen who have sex with mennatural historypharyngeal Chlamydia trachomatis

Identifiers

PMID34893806
PMCPMC9477446

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.