Evidence map›Paper›PMID 34893702›Full record

ArticleScientific reports2021

Photosensitization of a subcutaneous tumour by the natural anthraquinone parietin and blue light.

María Laura Mugas, Gustavo Calvo, Juliana Marioni, Mariela Céspedes, Florencia Martinez, Silvia Vanzulli, Daniel Sáenz, Gabriela Di Venosa, Susana Nuñez Montoya, Adriana Casas

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Divulging the potency of naturally derived photosensitizers in green PDT: an inclusive review Of mechanisms, advantages, and future prospects.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2025
    Review
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  4. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 7 institutions in 1 country.

María Laura MugasCentro de Investigaciones sobre Porfirinas y Porfirias (CIPYP), CONICET and Hospital de Clínicas José de San Martín, Universidad de Buenos Aires, Córdoba 2351 1er subsuelo, CP1120AAF, Buenos Aires, Argentina.
Gustavo CalvoCentro de Investigaciones sobre Porfirinas y Porfirias (CIPYP), CONICET and Hospital de Clínicas José de San Martín, Universidad de Buenos Aires, Córdoba 2351 1er subsuelo, CP1120AAF, Buenos Aires, Argentina.
Juliana MarioniDepartamento de Ciencias Farmacéuticas, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Haya de la Torre y Medina Allende, Ciudad Universitaria, Córdoba, Argentina.
Mariela CéspedesCentro de Investigaciones sobre Porfirinas y Porfirias (CIPYP), CONICET and Hospital de Clínicas José de San Martín, Universidad de Buenos Aires, Córdoba 2351 1er subsuelo, CP1120AAF, Buenos Aires, Argentina.
Florencia MartinezConsejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Córdoba, Argentina.
Silvia VanzulliInstituto de Investigaciones Hematológicas, Academia Nacional de Medicina, Buenos Aires, Argentina.
Daniel SáenzCentro de Investigaciones sobre Porfirinas y Porfirias (CIPYP), CONICET and Hospital de Clínicas José de San Martín, Universidad de Buenos Aires, Córdoba 2351 1er subsuelo, CP1120AAF, Buenos Aires, Argentina.
Gabriela Di VenosaCentro de Investigaciones sobre Porfirinas y Porfirias (CIPYP), CONICET and Hospital de Clínicas José de San Martín, Universidad de Buenos Aires, Córdoba 2351 1er subsuelo, CP1120AAF, Buenos Aires, Argentina.
Susana Nuñez MontoyaDepartamento de Ciencias Farmacéuticas, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Haya de la Torre y Medina Allende, Ciudad Universitaria, Córdoba, Argentina.
Adriana CasasCentro de Investigaciones sobre Porfirinas y Porfirias (CIPYP), CONICET and Hospital de Clínicas José de San Martín, Universidad de Buenos Aires, Córdoba 2351 1er subsuelo, CP1120AAF, Buenos Aires, Argentina. adriana@qb.fcen.uba.ar.
University of Buenos Aires · ARConsejo Nacional de Investigaciones Científicas y Técnicas · ARAcademia Nacional de Medicina · ARCentro Científico Tecnológico - Córdoba · ARHospital de Clínicas "José de San Martín" · ARInstituto Multidisciplinario de Biología Vegetal · ARUniversidad Nacional de Córdoba · AR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Photodynamic therapy (PDT) is an anticancer treatment involving administration of a tumour-localizing photosensitizer, followed by activation by light of a suitable wavelength. In previous work, we showed that the natural anthraquinone (AQ) Parietin (PTN), was a promising photosensitizer for photodynamic therapy of leukemic cells in vitro. The present work aimed to analyze the photosensitizing ability of PTN in the mammary carcinoma LM2 cells in vitro and in vivo in a model of subcutaneously implanted tumours. Photodynamic therapy mediated by parietin (PTN-PDT) (PTN 30 µM, 1 h and 1.78 J/cm

Indexed as

LightPhotochemotherapyAnimalsAnthraquinonesCell Line, TumorCell MovementCell ProliferationDisease Models, AnimalDose-Response Relationship, DrugEmodinFemaleMicePhotosensitizing AgentsSkin NeoplasmsTreatment OutcomeTumor Cells, CulturedAnthraquinonesEmodinPhotosensitizing Agents

Identifiers

PMID34893702
PMCPMC8664885
OpenAlexW4200365003

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.