Evidence map›Paper›PMID 34893678›Full record

ArticleScientific reports2021

Design, synthesis, and biological evaluation of novel urolithins derivatives as potential phosphodiesterase II inhibitors.

Long Tang, Jianchun Jiang, Guoqiang Song, Yajing Wang, Ziheng Zhuang, Ying Tan, Yan Xia, Xianfeng Huang, Xiaoqing Feng

Abstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Long Tang *Institute of Chemical Industry of Forest Products, Chinese Academy of Forestry, Nanjing, 210042, China.
Jianchun JiangInstitute of Chemical Industry of Forest Products, Chinese Academy of Forestry, Nanjing, 210042, China.
Guoqiang Song *School of Pharmaceutical Engineering & Life Science, Changzhou University, Changzhou, 213164, China.
Yajing Wang *School of Pharmaceutical Engineering & Life Science, Changzhou University, Changzhou, 213164, China.
Ziheng ZhuangSchool of Pharmaceutical Engineering & Life Science, Changzhou University, Changzhou, 213164, China.
Ying TanSchool of Pharmaceutical Engineering & Life Science, Changzhou University, Changzhou, 213164, China.
Yan XiaSchool of Pharmaceutical Engineering & Life Science, Changzhou University, Changzhou, 213164, China.
Xianfeng HuangSchool of Pharmaceutical Engineering & Life Science, Changzhou University, Changzhou, 213164, China.
Xiaoqing FengSchool of Pharmaceutical Engineering & Life Science, Changzhou University, Changzhou, 213164, China. fxqfw@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A series of urolithins derivatives were designed and synthesized, and their structures have been confirmed by

Indexed as

Chemistry Techniques, SyntheticDrug DesignBinding SitesEnzyme ActivationExonucleasesModels, MolecularMolecular ConformationMolecular StructurePhosphodiesterase InhibitorsProtein BindingStructure-Activity RelationshipExonucleasesPhosphodiesterase Inhibitorsspleen exonuclease

Identifiers

PMID34893678
PMCPMC8664850

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.