Evidence map›Paper›PMID 34893663›Full record

ArticleScientific reports2021

CXCR4 blockade reduces the severity of murine heart allograft rejection by plasmacytoid dendritic cell-mediated immune regulation.

Jian Fu, Christian H K Lehmann, Xinning Wang, Mandy Wahlbuhl, Ida Allabauer, Benjamin Wilde, Lukas Amon, Sebastian Dolff, Robert Cesnjevar, Andreas Kribben and 6 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. T Cells With ActivatedFrontiers in immunology · 2022
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 3 countries.

Jian Fu *Department of Nephrology, University Hospital Essen, University Duisburg-Essen, Essen, Germany.
Christian H K Lehmann *Department of Dermatology, University Hospital Erlangen, Friedrich-Alexander University of Erlangen-Nürnberg, Research Module II, Hartmannstr. 14, 91052, Erlangen, Germany. Christian.Lehmann@uk-erlangen.de.
Xinning WangDepartment of Nephrology, University Hospital Essen, University Duisburg-Essen, Essen, Germany.
Mandy WahlbuhlDepartment for Pediatric and Adolescent Medicine, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg, Loschgestrasse 15, 91054, Erlangen, Germany.
Ida AllabauerDepartment for Pediatric and Adolescent Medicine, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg, Loschgestrasse 15, 91054, Erlangen, Germany.
Benjamin WildeDepartment of Nephrology, University Hospital Essen, University Duisburg-Essen, Essen, Germany.
Lukas AmonDepartment of Dermatology, University Hospital Erlangen, Friedrich-Alexander University of Erlangen-Nürnberg, Research Module II, Hartmannstr. 14, 91052, Erlangen, Germany.
Sebastian DolffDepartment of Infectious Diseases, West German Centre of Infectious Diseases, Universitätsmedizin Essen, University Duisburg-Essen, Essen, Germany.
Robert CesnjevarDepartment of Pediatric Cardiac Surgery, Friedrich-Alexander University of Erlangen-Nürnberg (FAU), University Hospital Erlangen, Erlangen, Germany.
Andreas KribbenDepartment of Nephrology, University Hospital Essen, University Duisburg-Essen, Essen, Germany.
Joachim WoelfleDepartment for Pediatric and Adolescent Medicine, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg, Loschgestrasse 15, 91054, Erlangen, Germany.
Wolfgang RascherDepartment for Pediatric and Adolescent Medicine, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg, Loschgestrasse 15, 91054, Erlangen, Germany.
Peter F HoyerDepartment of Pediatrics II, Pediatric Nephrology, Gastroenterology, Endocrinology and Transplant Medicine, Children's Hospital Essen, University Duisburg-Essen, Duisburg, Germany.
Diana DudziakDepartment of Dermatology, University Hospital Erlangen, Friedrich-Alexander University of Erlangen-Nürnberg, Research Module II, Hartmannstr. 14, 91052, Erlangen, Germany.
Oliver WitzkeDepartment of Infectious Diseases, West German Centre of Infectious Diseases, Universitätsmedizin Essen, University Duisburg-Essen, Essen, Germany.
André HoerningDepartment for Pediatric and Adolescent Medicine, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg, Loschgestrasse 15, 91054, Erlangen, Germany. andre.hoerning@uk-erlangen.de.
Universitätsklinikum Erlangen · DEUniversity of Duisburg-Essen · DEFriedrich-Alexander-Universität Erlangen-Nürnberg · DEChildren's Hospital of Zhejiang University · CNUniversity Children's Hospital Zurich · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Allograft-specific regulatory T cells (T

Indexed as

Heart TransplantationImmunomodulationAllograftsAnimalsBenzylaminesBiomarkersCyclamsDendritic CellsDisease Models, AnimalDrug SynergismGraft RejectionGraft SurvivalMicePrognosisReceptors, CXCR4SirolimusBenzylaminesBiomarkersCXCR4 protein, mouseCyclamsplerixaforReceptors, CXCR4Sirolimus

Identifiers

PMID34893663
PMCPMC8664946
OpenAlexW4200024861

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.