ArticleNature communications2021
Interdependent iron and phosphorus availability controls photosynthesis through retrograde signaling.
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed, 115 citations in OpenAlex.
- A beneficial bacterium mitigates drought stress by upregulating the flavonoid biosynthetic pathway inPlant signaling & behavior · 2026Article
- Sulfur in dialogue with phosphorus, nitrogen, and iron: regulatory networks in plant nutrient homeostasis.Journal of experimental botany · 2026Review
- Harnessing natural variation for photosynthetic improvement in next-generation crop breeding.Journal of integrative plant biology · 2026Review
- Evaluating Multi-Benefit Cover Crop Management Models for Citrus Sustainable Management: A Field Study from Central China.Plants (Basel, Switzerland) · 2026Article
- PPSR1 Protein Functions as an Important Regulator to Enhance Plant Growth Performance Under N, P, and K Deficient Stress Conditions.Plant biotechnology journal · 2026Article
- A Reference-Free Algorithm Discovers Regulation in the Plant Transcriptome.Plant direct · 2026Article
- Aluminum Alleviation of Iron Deficiency Chlorosis Is Conserved in Wild Rice RelativePlants (Basel, Switzerland) · 2026Article
- Coordination of genome stability: Novel communication pathways between chloroplasts and other compartments in plant cells.Fundamental research · 2026Review
- Evaluation of phosphorus sources in tomato plants inoculated with plant growth-promoting rhizobacteria.PeerJ · 2026Article
- Single-cell transcriptional decoding of iron deficiency responses in maize root tips.Plant cell reports · 2025Article
- Age-dependent differential iron deficiency responses of rosette leaves during reproductive stages in Arabidopsis thaliana.Journal of experimental botany · 2025Article
- Integrative Analysis of Transcriptomic and Metabolomic Profiles Uncovers the Mechanism of Color Variation in the Tea Plant Callus.Plants (Basel, Switzerland) · 2025Article
- The thylakoid- and pyrenoid-localized phosphate transporter PHT4-9 is essential for photosynthesis in Chlamydomonas.Plant physiology · 2025Article
- Genome-Wide Identification and Expression Analysis of the Phosphate Transporter Gene Family inInternational journal of molecular sciences · 2025Article
- Stress on the Endoplasmic Reticulum Impairs the Photosynthetic Efficiency of Chlamydomonas.International journal of molecular sciences · 2024Article
- Genome-Wide Transcriptional Profiling and Functional Analysis Reveal That OsPHT4;4 Is Critical for the Growth and Development of Rice.International journal of molecular sciences · 2024Article
- Chloroplastic ascorbate modifies plant metabolism and may act as a metabolite signal regardless of oxidative stress.Plant physiology · 2024Article
- Genetically manipulated chloroplast stromal phosphate levels alter photosynthetic efficiency.Plant physiology · 2024Article
- Transcriptome analysis of Pennisetum americanum × Pennisetum purpureum and Pennisetum americanum leaves in response to high-phosphorus stress.BMC plant biology · 2024Article
- The Phosphorus-Iron Nexus: Decoding the Nutrients Interaction in Soil and Plant.International journal of molecular sciences · 2024Review
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Iron deficiency hampers photosynthesis and is associated with chlorosis. We recently showed that iron deficiency-induced chlorosis depends on phosphorus availability. How plants integrate these cues to control chlorophyll accumulation is unknown. Here, we show that iron limitation downregulates photosynthesis genes in a phosphorus-dependent manner. Using transcriptomics and genome-wide association analysis, we identify two genes, PHT4;4 encoding a chloroplastic ascorbate transporter and bZIP58, encoding a nuclear transcription factor, which prevent the downregulation of photosynthesis genes leading to the stay-green phenotype under iron-phosphorus deficiency. Joint limitation of these nutrients induces ascorbate accumulation by activating expression of an ascorbate biosynthesis gene, VTC4, which requires bZIP58. Furthermore, we demonstrate that chloroplastic ascorbate transport prevents the downregulation of photosynthesis genes under iron-phosphorus combined deficiency through modulation of ROS homeostasis. Our study uncovers a ROS-mediated chloroplastic retrograde signaling pathway to adapt photosynthesis to nutrient availability.
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