Evidence map›Paper›PMID 34893634›Full record

ArticleScientific reports2021

The epidemic volatility index, a novel early warning tool for identifying new waves in an epidemic.

Polychronis Kostoulas, Eletherios Meletis, Konstantinos Pateras, Paolo Eusebi, Theodoros Kostoulas, Luis Furuya-Kanamori, Niko Speybroeck, Matthew Denwood, Suhail A R Doi, Christian L Althaus and 8 more

Abstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. One health investigation following a cluster of Crimean-Congo haemorrhagic fever, North Macedonia, July to November 2023.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Polychronis KostoulasFaculty of Public Health, University of Thessaly, Thessaly, Greece. pkost@uth.gr.
Eletherios MeletisFaculty of Public Health, University of Thessaly, Thessaly, Greece.
Konstantinos PaterasFaculty of Public Health, University of Thessaly, Thessaly, Greece.
Paolo EusebiDepartment of Medicine and Surgery, University of Perugia, Perugia, Italy.
Theodoros KostoulasDepartment of Information and Communication Systems Engineering, University of the Aegean, Aegean, Greece.
Luis Furuya-KanamoriUQ Centre for Clinical Research, Faculty of Medicine, The University of Queensland, Herston, Australia.
Niko SpeybroeckResearch Institute of Health and Society (IRSS), Université Catholique de Louvain, 1200, Brussels, Belgium.
Matthew DenwoodDepartment of Veterinary and Animal Sciences, University of Copenhagen, Copenhagen, Denmark.
Suhail A R DoiDepartment of Population Medicine, College of Medicine, QU Health, Qatar University, Doha, Qatar.
Christian L AlthausInstitute of Social and Preventive Medicine, University of Bern, Bern, Switzerland.
Carsten KirkebyDepartment of Veterinary and Animal Sciences, University of Copenhagen, Copenhagen, Denmark.
Pejman RohaniOdum School of Ecology, University of Georgia, Athens, GA, 30602, USA.
Navneet K DhandSydney School of Veterinary Science, The University of Sydney, Camden, NSW, Australia.
José L PeñalvoUnit of Noncommunicable Diseases, Department of Public Health, Institute of Tropical Medicine, Antwerp, Belgium.
Lehana ThabaneDepartment of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.
Slimane BenMiledPasteur Institute, University of Tunis El Manar, Tunis, Tunisia.
Hamid SharifiHIV/STI Surveillance Research Center, and WHO Collaborating Center for HIV Surveillance, Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman, Iran.
Stephen D WalterDepartment of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.

Funding

European Cooperation in Science and Technology CA18208
6 · The paper itself

Abstract

Early warning tools are crucial for the timely application of intervention strategies and the mitigation of the adverse health, social and economic effects associated with outbreaks of epidemic potential such as COVID-19. This paper introduces, the Epidemic Volatility Index (EVI), a new, conceptually simple, early warning tool for oncoming epidemic waves. EVI is based on the volatility of newly reported cases per unit of time, ideally per day, and issues an early warning when the volatility change rate exceeds a threshold. Data on the daily confirmed cases of COVID-19 are used to demonstrate the use of EVI. Results from the COVID-19 epidemic in Italy and New York State are presented here, based on the number of confirmed cases of COVID-19, from January 22, 2020, until April 13, 2021. Live daily updated predictions for all world countries and each of the United States of America are publicly available online. For Italy, the overall sensitivity for EVI was 0.82 (95% Confidence Intervals: 0.75; 0.89) and the specificity was 0.91 (0.88; 0.94). For New York, the corresponding values were 0.55 (0.47; 0.64) and 0.88 (0.84; 0.91). Consecutive issuance of early warnings is a strong indicator of main epidemic waves in any country or state. EVI's application to data from the current COVID-19 pandemic revealed a consistent and stable performance in terms of detecting new waves. The application of EVI to other epidemics and syndromic surveillance tasks in combination with existing early warning systems will enhance our ability to act swiftly and thereby enhance containment of outbreaks.

Indexed as

PandemicsCOVID-19HumansItalyNew YorkPredictive Value of TestsTime Factors

Identifiers

PMID34893634
PMCPMC8664819

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.