Evidence map›Paper›PMID 34893625›Full record

ArticleNature communications2021

Type-I collagen produced by distinct fibroblast lineages reveals specific function during embryogenesis and Osteogenesis Imperfecta.

Yang Chen, Sujuan Yang, Sara Lovisa, Catherine G Ambrose, Kathleen M McAndrews, Hikaru Sugimoto, Raghu Kalluri

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers.

0numbers the graph read from it
0cells of the map it votes in
70citing papers in PubMed
11.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

70 citing papers in PubMed, 121 citations in OpenAlex.

  1. Article
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  4. Review
  5. Article
  6. Toward Computationally Complete Spatial Omics.bioRxiv : the preprint server for biology · 2026
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  8. Oral intake of Heat-KilledJournal of microbiology and biotechnology · 2026
    Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. PDGFRαAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Review
  20. Review

10 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Yang ChenDepartment of Cancer Biology, University of Texas MD Anderson Cancer Center, Houston, TX, 77054, USA.ORCID http://orcid.org/0000-0003-4441-5614
Sujuan YangDepartment of Cancer Biology, University of Texas MD Anderson Cancer Center, Houston, TX, 77054, USA.
Sara LovisaDepartment of Cancer Biology, University of Texas MD Anderson Cancer Center, Houston, TX, 77054, USA.ORCID http://orcid.org/0000-0001-7776-2896
Catherine G AmbroseDepartment of Orthopaedic Surgery, University of Texas Health Science Center at Houston, Houston, TX, USA.
Kathleen M McAndrewsDepartment of Cancer Biology, University of Texas MD Anderson Cancer Center, Houston, TX, 77054, USA.ORCID http://orcid.org/0000-0002-4092-4991
Hikaru SugimotoDepartment of Cancer Biology, University of Texas MD Anderson Cancer Center, Houston, TX, 77054, USA.
Raghu KalluriDepartment of Cancer Biology, University of Texas MD Anderson Cancer Center, Houston, TX, 77054, USA. rkalluri@mdanderson.org.ORCID http://orcid.org/0000-0002-2190-547X
The University of Texas MD Anderson Cancer Center · USThe University of Texas Health Science Center at Houston · US

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Scott Kopetz · 1985 to 2026
$290.8M
The RAS and P13K Pathways in Pancreatic AdenocarcinomaP01CA117969 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI DEPINHO, RONALD ANTHONY · 2006 to 2025
$41.7M
NCI NIH HHS P01 CA117969NCI NIH HHS P30 CA016672
6 · The paper itself

Abstract

Type I collagen (Col1) is the most abundant protein in mammals. Col1 contributes to 90% of the total organic component of bone matrix. However, the precise cellular origin and functional contribution of Col1 in embryogenesis and bone formation remain unknown. Single-cell RNA-sequencing analysis identifies Fap

Indexed as

AnimalsBone MarrowCell LineageCollagen Type ICollagen Type I, alpha 1 ChainEmbryonic DevelopmentFemaleFemurFibroblastsHumansMaleMiceMice, KnockoutMice, TransgenicOsteogenesisOsteogenesis ImperfectaCol1a1 protein, mouseCollagen Type ICollagen Type I, alpha 1 Chain

Identifiers

PMID34893625
PMCPMC8664945
OpenAlexW4200274289

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.