ArticleNature communications2021
From amino acid mixtures to peptides in liquid sulphur dioxide on early Earth.
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 29 citations in OpenAlex.
- Spatial distribution of glucose and amino acids within all-aqueous emulsions directs the Maillard reaction and oxidation pathways.Communications chemistry · 2026Article
- Tailored Phosphate Leaving Groups Direct Pathway-Dependent Self-Assembly.Journal of the American Chemical Society · 2026Article
- Selective peptide bond formation via side chain reactivity and self-assembly of abiotic phosphates.Nature communications · 2025Article
- On the Origin of Life on Earth: The Nanozymes Hypothesis, and More.Research (Washington, D.C.) · 2025Review
- Phosphoric acid salts of amino acids as a source of oligopeptides on the early Earth.Communications chemistry · 2024Article
- From Zero to Hero: The Cyanide-Free Formation of Amino Acids and Amides from Acetylene, Ammonia and Carbon Monoxide in Aqueous Environments in a Simulated Hadean Scenario.Life (Basel, Switzerland) · 2024Article
- Construction of chiral capillary electrochromatography microsystems based on Aspergillus sp. CM96.Mikrochimica acta · 2023Article
- Selective Synthesis of Lysine Peptides and the Prebiotically Plausible Synthesis of Catalytically Active Diaminopropionic Acid Peptide Nitriles in Water.Journal of the American Chemical Society · 2023Article
- Phosphorylation in liquid sulfur dioxide under prebiotically plausible conditions.Communications chemistry · 2022Article
- Did Homocysteine Take Part in the Start of the Synthesis of Peptides on the Early Earth?Biomolecules · 2022Article
- New Signatures of Bio-Molecular Complexity in the Hypervelocity Impact Ejecta of Icy Moon Analogues.Life (Basel, Switzerland) · 2022Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The formation of peptide bonds is one of the most important biochemical reaction steps. Without the development of structurally and catalytically active polymers, there would be no life on our planet. However, the formation of large, complex oligomer systems is prevented by the high thermodynamic barrier of peptide condensation in aqueous solution. Liquid sulphur dioxide proves to be a superior alternative for copper-catalyzed peptide condensations. Compared to water, amino acids are activated in sulphur dioxide, leading to the incorporation of all 20 proteinogenic amino acids into proteins. Strikingly, even extremely low initial reactant concentrations of only 50 mM are sufficient for extensive peptide formation, yielding up to 2.9% of dialanine in 7 days. The reactions carried out at room temperature and the successful use of the Hadean mineral covellite (CuS) as a catalyst, suggest a volcanic environment for the formation of the peptide world on early Earth.
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