ArticleNature communications2021
Acute RyR1 Ca
2 registry-linked trialsOpen access · goldAbstract read
In one paragraph
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 24 papers.
0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Combined Effect of Exercise Intensity With Nutritional Supplementation on Skeletal Muscle Function
The Effect of Olive Leaf Extract Supplementation on Training-induced Skeletal Muscle Functional and Molecular Adaptations in Healthy Volunteers
Who cites it
24 citing papers in PubMed, 43 citations in OpenAlex.
- Sprint interval exercise disrupts mitochondrial ultrastructure driving a unique mitochondrial stress response and remodelling in men.Nature communications · 2025Trial
- Exercise intensity modulates interorgan communication and is associated with cardiometabolic health outcomes in humans.Cell reports. Medicine · 2026Article
- Mechanotransduction Failure and Molecular Rescue in Gastric Cancer: Kinetotherapy Across the IL-6/STAT3-Myostatin/ACVR2B-Akt/mTOR Axis.Medical sciences (Basel, Switzerland) · 2026Review
- Mitochondria-sarcoplasmic reticulum crosstalk as a modulator of skeletal muscle mass.Journal of physiology and biochemistry · 2026Review
- Advances in electrical stimulation-based therapeutic technologies for sarcopenia prevention and treatment.Bioactive materials · 2026Review
- Oleuropein-based olive leaf extract enhances muscle mitochondrial bioenergetics response to moderate - but not maximal - intensity exercise in humans.The Journal of physiology · 2026Article
- Neuromuscular Mechanisms and Oxidative Stress in Skeletal Muscle Atrophy: Emerging Stem Cell and Gene-Based Therapeutic Strategies.Muscles (Basel, Switzerland) · 2026Review
- Decadelong low basal ganglia NAA/tCr from elevated tCr supports ATP depletion from mitochondrial dysfunction and neuroinflammation in Gulf War illness.Scientific reports · 2025Article
- Hypothalamic Astrocytes Exhibit Glycolytic Features Making Them Prone for Glucose Sensing.Glia · 2025Article
- Phosphorylation of RYR1 at SerScience signaling · 2025Article
- Padua Days on Muscle and Mobility Medicine, March 25-29, 2025, Hotel Petrarca, Euganean Thermae, Italy: Program and Abstracts.European journal of translational myology · 2025Article
- Muscle-specific Ryanodine receptor 1 properties underlie limb-girdle muscular dystrophy 2B/R2 progression.Nature communications · 2025Article
- Stable oxidative posttranslational modifications alter the gating properties of RyR1.The Journal of general physiology · 2024Article
- Myopathic manifestations across the adult lifespan of patients with malignant hyperthermia susceptibility: a narrative review.British journal of anaesthesia · 2024Review
- Mitochondrial Calcium Regulation of Cardiac Metabolism in Health and Disease.Physiology (Bethesda, Md.) · 2024Review
- BCL2L13 at endoplasmic reticulum-mitochondria contact sites regulates calcium homeostasis to maintain skeletal muscle function.iScience · 2024Article
- Cyclo His-Pro Attenuates Muscle Degeneration in Murine Myopathy Models.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Unveiling the emerging role of curcumin to alleviate ochratoxin A-induced muscle toxicity in grass carp (Ctenopharyngodon idella): in vitro and in vivo studies.Journal of animal science and biotechnology · 2024Article
- Disuse-Induced Muscle Fatigue: Facts and Assumptions.International journal of molecular sciences · 2024Review
- Ryanodine receptor dysfunction causes senescence and fibrosis in Duchenne dilated cardiomyopathy.Journal of cachexia, sarcopenia and muscle · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 5 institutions in 3 countries.
Nadège ZanouInstitute of Sport Sciences and Department of Biomedical Sciences, University of Lausanne, Lausanne, Switzerland. nad.zanou.mdphd@gmail.com.ORCID http://orcid.org/0000-0001-6626-3127
Haikel DridiDepartment of Physiology and Cellular Biophysics, Clyde and Helen Wu Center for Molecular Cardiology, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.ORCID http://orcid.org/0000-0001-9533-7367
Steven ReikenDepartment of Physiology and Cellular Biophysics, Clyde and Helen Wu Center for Molecular Cardiology, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.
Tanes Imamura de LimaLaboratory of Integrative Systems Physiology (LISP), École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.
Chris DonnellyInstitute of Sport Sciences and Department of Biomedical Sciences, University of Lausanne, Lausanne, Switzerland.ORCID http://orcid.org/0000-0002-5392-7876
Umberto De MarchiNestlé Research - École Polytechnique Fédérale de Lausanne (EPFL), Innovation Park, Lausanne, Switzerland.ORCID http://orcid.org/0000-0002-6011-5446
Manuele FerriniInstitute of Sport Sciences and Department of Biomedical Sciences, University of Lausanne, Lausanne, Switzerland.ORCID http://orcid.org/0000-0001-8291-6618
Jeremy VidalInstitute of Sport Sciences and Department of Biomedical Sciences, University of Lausanne, Lausanne, Switzerland.
Leah SittenfeldDepartment of Physiology and Cellular Biophysics, Clyde and Helen Wu Center for Molecular Cardiology, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.
Jerome N FeigeNestlé Research - École Polytechnique Fédérale de Lausanne (EPFL), Innovation Park, Lausanne, Switzerland.ORCID http://orcid.org/0000-0002-4751-264X
Pablo M Garcia-RovesDepartment of Physiological Sciences, School of Medicine and Health Sciences, University of Barcelona and Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet del Llobregat, Barcelona, Spain.ORCID http://orcid.org/0000-0002-8371-2067
Isabel C Lopez-MejiaCenter for Integrative Genomics, University of Lausanne, Lausanne, Switzerland.ORCID http://orcid.org/0000-0001-5918-0227
Andrew R MarksDepartment of Physiology and Cellular Biophysics, Clyde and Helen Wu Center for Molecular Cardiology, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.
Johan AuwerxLaboratory of Integrative Systems Physiology (LISP), École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.ORCID http://orcid.org/0000-0002-5065-5393
Bengt KayserInstitute of Sport Sciences and Department of Biomedical Sciences, University of Lausanne, Lausanne, Switzerland.ORCID http://orcid.org/0000-0002-9776-7501
Nicolas PlaceInstitute of Sport Sciences and Department of Biomedical Sciences, University of Lausanne, Lausanne, Switzerland. nicolas.place@unil.ch.ORCID http://orcid.org/0000-0001-9044-0621
University of Lausanne · CHÉcole Polytechnique Fédérale de Lausanne · CHColumbia University · USBellvitge University Hospital · ESColumbia University Irving Medical Center · US
Funding
MOLECULAR BASIS OF HEART FAILURER01HL061503 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MARKS, ANDREW ROBERT · 1998 to 2016
$6.5MExploring the Molecular Physiology of Atrial FibrillationR01HL140934 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MARKS, ANDREW ROBERT, MARX, STEVEN O · 2018 to 2025
$6.0MTraining in Cardiovascular Translational ResearchT32HL120826 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MARKS, ANDREW ROBERT, TABAS, IRA A · 2014 to 2023
$4.7MStructure-function analysis for elucidating pathogenicity of cardiac ryanodine receptor genetic variantsR01HL145473 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MARKS, ANDREW ROBERT, SHEPARD, KENNETH L · 2019 to 2022
$3.1MLIVOPT -- LIVer cirrhosis - Optimizing Prediction of Patient OuTcomesR01AG070194 · NIA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI LADNER, DANIELA P, MEHROTRA, SANJAY · 2021 to 2025
$3.1MRyanodine Receptor Defects in Cardiomyopathy Caused by Lamin A/C Gene MutationsR01HL142903 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MARKS, ANDREW ROBERT, WORMAN, HOWARD J · 2019 to 2022
$1.8MCalcium and the physiology of diabetesR01DK118240 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MARKS, ANDREW ROBERT · 2019 to 2022
$1.6MSummer Program for Under Represented Students (SPURS)R25NS076445 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Wesley B Grueber, STEVEN A SIEGELBAUM · 2012 to 2026
$1.4MNHLBI NIH HHS R01 HL061503NHLBI NIH HHS R01 HL140934NHLBI NIH HHS R01 HL142903NHLBI NIH HHS R01 HL145473NHLBI NIH HHS T32 HL120826NIA NIH HHS R01 AG070194NIDDK NIH HHS R01 DK118240NINDS NIH HHS R25 NS076445
Abstract
Sustained ryanodine receptor (RyR) Ca
Indexed as
AnimalsCalciumCalcium SignalingCell LineEndoplasmic ReticulumEnergy MetabolismFemaleHumansMaleMiceMice, Inbred C57BLMitochondriaMuscle WeaknessNADProteomicsRyanodine Receptor Calcium Release ChannelCalciumNADryanodine receptor 1, mouseRyanodine Receptor Calcium Release ChannelRYR1 protein, humanTacrolimus Binding Proteins
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
NCT05350566ClinicalTrials.gov
NCT07729072ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.