ArticleNature communications2021
Distinct roles of KLF4 in mesenchymal cell subtypes during lung fibrogenesis.
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Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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40citing papers in PubMed
3.4field-weighted citation impact, top 6% of its field
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Who cites it
40 citing papers in PubMed, 56 citations in OpenAlex.
- Regulatory roles and translational potential of the Kruppel-like factor family in liver disease.iLIVER · 2026Review
- Novel netrin-1-Unc5b-Klf4 axis balances AT2 survival in experimental bronchopulmonary dysplasia.American journal of respiratory cell and molecular biology · 2026Article
- Resident mesenchymal progenitor cells require autocrine IGF-I in homeostatic and regenerating skeletal muscle.Stem cell reports · 2026Article
- Inflammation reprograms fibro-adipogenic progenitors to sustain immunopathogenic niches in myositis.Cell death & disease · 2026Article
- Article
- Transcriptomic and functional responses of human airway cells to vaped ∆8-THC and its oxidation product ∆8-THCQ.Scientific reports · 2026Article
- Clec3b⁺ fibroblasts are the primary effectors of portal fibrosis following activation via a KLF4/periostin axis.Nature communications · 2026Article
- Decoding organ fibrosis: mechanistic insights and emerging therapeutic strategies.Signal transduction and targeted therapy · 2026Review
- Cadmium exposure induces renal fibrosis by inhibiting hsa_circ_0075684/miR-363-3p/KLF4 signaling pathway.Scientific reports · 2026Article
- PDGFRβ in Stem Cell Microenvironments: Cross-Tissue Evidence and Hypotheses for the Limbal Stem Cell Niche.Stem cells international · 2026Review
- β-III tubulin identifies anti-fibrotic state of pericytes in pulmonary fibrosis.Research square · 2025Article
- A soft-stiff patterned bioengineering model reveals kinase pathways driving directional cell migration in pulmonary arterial hypertension.Biomaterials science · 2025Article
- Comprehensive transcription factor perturbations recapitulate fibroblast transcriptional states.Nature genetics · 2025Article
- A Functional VariantAmerican journal of respiratory cell and molecular biology · 2025Article
- PIEZO1 mediates periostin+ myofibroblast activation and pulmonary fibrosis in mice.The Journal of clinical investigation · 2025Article
- Recent progress in exosomal non-coding RNAs research related to idiopathic pulmonary fibrosis.Frontiers in genetics · 2025Review
- Krüppel-like factors family in health and disease.MedComm · 2024Review
- Optimized rAAV8 targeting acinar KLF4 ameliorates fibrosis in chronic pancreatitis via exosomes-enriched let-7s suppressing pancreatic stellate cells activation.Molecular therapy : the journal of the American Society of Gene Therapy · 2024Article
- Endothelial HIFα/PDGF-B to smooth muscle Beclin1 signaling sustains pathological muscularization in pulmonary hypertension.JCI insight · 2024Article
- Dedifferentiated early postnatal lung myofibroblasts redifferentiate in adult disease.Frontiers in cell and developmental biology · 2024Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Rachana R ChandranYale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, 06511, USA.
Yi XieYale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, 06511, USA.ORCID http://orcid.org/0000-0002-2641-5859
Eunate Gallardo-VaraYale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, 06511, USA.ORCID http://orcid.org/0000-0003-4733-0878
Taylor AdamsSection of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, 06520, USA.
Rolando Garcia-MilianBioinformatics Support Program, Yale University School of Medicine, New Haven, CT, 06520, USA.ORCID http://orcid.org/0000-0003-1557-566X
Inamul KabirYale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, 06511, USA.ORCID http://orcid.org/0000-0001-6207-1785
Abdul Q SheikhYale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, 06511, USA.
Naftali KaminskiSection of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, 06520, USA.ORCID http://orcid.org/0000-0001-5917-4601
Kathleen A MartinYale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, 06511, USA.
Erica L HerzogSection of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, 06520, USA.
Daniel M GreifYale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, 06511, USA. daniel.greif@yale.edu.ORCID http://orcid.org/0000-0002-9842-3751
Yale University · USPfizer (United States) · US
Funding
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9MNovel vascular smooth muscle cell progenitors in development and diseaseR35HL150766 · NHLBI · YALE UNIVERSITY · PI Daniel Greif · 2020 to 2026
$7.0MSmooth muscle progenitors in vascular remodelingR01HL133016 · NHLBI · YALE UNIVERSITY · PI GREIF, DANIEL · 2016 to 2019
$1.7MPathological arterial muscularization and the role of integrinsR01HL125815 · NHLBI · YALE UNIVERSITY · PI GREIF, DANIEL · 2015 to 2018
$1.7MMural cell TGF-beta-mediated signaling and neonatal intracerebral hemorrhageR21NS088854 · NINDS · YALE UNIVERSITY · PI GREIF, DANIEL · 2014 to 2015
$458kMyofibroblasts in pulmonary fibrosis: origin, clones and KLF4F32HL132532 · NHLBI · YALE UNIVERSITY · PI RADHAMANI CHANDRAN, RACHANA · 2016 to 2018
$174kNCATS NIH HHS UL1 TR001863NHLBI NIH HHS F32 HL132532NHLBI NIH HHS R01 HL125815NHLBI NIH HHS R01 HL133016NHLBI NIH HHS R35 HL150766NINDS NIH HHS R21 NS088854
Abstract
During lung fibrosis, the epithelium induces signaling to underlying mesenchyme to generate excess myofibroblasts and extracellular matrix; herein, we focus on signaling in the mesenchyme. Our studies indicate that platelet-derived growth factor receptor (PDGFR)-β
Indexed as
AnimalsCell ProliferationDisease Models, AnimalDown-RegulationExtracellular MatrixFemaleFibroblastsFibrosisHumansKruppel-Like Factor 4LungLung InjuryMaleMesenchymal Stem CellsMiceMice, Inbred C57BLKLF4 protein, humanKlf4 protein, mouseKruppel-Like Factor 4Receptor, Platelet-Derived Growth Factor betaTransforming Growth Factor beta
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.