Evidence map›Paper›PMID 34893527›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2022

ABCB10 Loss Reduces CD4

Wenxiang Sun, Xuan Jia, Marc Liesa, Dean Tantin, Diane M Ward

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 58% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Wenxiang SunDepartment of Pathology, School of Medicine, University of Utah, Salt Lake City, UT.ORCID 0000-0001-9037-0942
Xuan JiaDepartment of Pathology, School of Medicine, University of Utah, Salt Lake City, UT.ORCID 0000-0002-3986-0687
Marc LiesaDivision of Endocrinology, Department of Medicine, University of California, Los Angeles, Los Angeles, CA.ORCID 0000-0002-5909-8570
Dean TantinDepartment of Pathology, School of Medicine, University of Utah, Salt Lake City, UT; dean.tantin@path.utah.edu diane.mcveyward@path.utah.edu.ORCID 0000-0003-1354-8385
Diane M WardDepartment of Pathology, School of Medicine, University of Utah, Salt Lake City, UT; dean.tantin@path.utah.edu diane.mcveyward@path.utah.edu.
University of Utah · USUniversity of California, Los Angeles · US

Funding

Proteomics CoreU54DK110858 · NIDDK · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Anna E Beaudin, JAMES Eric COX · 2016 to 2026
$8.6M
Role of Transcription Coactivator OCA-B in Gene Poising and Immunological MemoryR01AI100873 · NIAID · UNIVERSITY OF UTAH · PI TANTIN, DEAN · 2013 to 2022
$3.8M
Role of the heme-related mitochondrial antioxidant ABCB10 in alcoholic liver diseaseR01AA026914 · NIAAA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SHIRIHAI, ORIAN S · 2019 to 2022
$1.4M
NIAAA NIH HHS R01 AA026914NIAID NIH HHS R01 AI100873NIDDK NIH HHS U54 DK110858
6 · The paper itself

Abstract

T cells must shift their metabolism to respond to infections and tumors and to undergo memory formation. The ATP-binding cassette transporter ABCB10 localizes to the mitochondrial inner membrane, where it is thought to export a substrate important in heme biosynthesis and metabolism, but its role in T cell development and activation is unknown. In this article, we use a combination of methods to study the effect of ABCB10 loss in primary and malignantly transformed T cells. Although

Indexed as

AnimalsATP-Binding Cassette TransportersCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCell LineCRISPR-Cas SystemsCytokinesGlycolysisHumansImmunologic MemoryJurkat CellsLymphocyte ActivationMiceMice, Inbred C57BLMice, KnockoutAbcb10 protein, mouseATP-Binding Cassette TransportersCytokines

Identifiers

PMID34893527
PMCPMC8755610
OpenAlexW4200027498

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.