Evidence map›Paper›PMID 34893084›Full record

ReviewGenes and environment : the official journal of the Japanese Environmental Mutagen Society2021

Epigenetics in neurodegenerative disorders induced by pesticides.

Guangxia Yu, Qianqian Su, Yao Chen, Lingyan Wu, Siying Wu, Huangyuan Li

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Genes and environment : the official journal of the Japanese Environmental Mutagen Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
6.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.

  1. Pooled it
  2. Chlorpyrifos and Chlorpyrifos-Oxon: A Widening Spectrum of Toxicity.International journal of molecular sciences · 2026
    Review
  3. Review
  4. Review
  5. Review
  6. Article
  7. Review
  8. Article
  9. Current knowledges in pharmaconutrition: "Frontiers in nutrition · 2023
    Review
  10. Gene×environment interactions in autism spectrum disorders.Current topics in developmental biology · 2023
    Review
  11. Review
  12. Review
  13. Review
  14. Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Guangxia YuFujian Key Lab of Environmental Factors and Cancer, School of Public Health, Fujian Medical University, Fuzhou, Fujian Province, China.
Qianqian SuFujian Key Lab of Environmental Factors and Cancer, School of Public Health, Fujian Medical University, Fuzhou, Fujian Province, China.
Yao ChenFujian Key Lab of Environmental Factors and Cancer, School of Public Health, Fujian Medical University, Fuzhou, Fujian Province, China.
Lingyan WuFujian Key Lab of Environmental Factors and Cancer, School of Public Health, Fujian Medical University, Fuzhou, Fujian Province, China.
Siying WuFujian Key Lab of Environmental Factors and Cancer, School of Public Health, Fujian Medical University, Fuzhou, Fujian Province, China. fmuwsy@163.com.
Huangyuan LiFujian Key Lab of Environmental Factors and Cancer, School of Public Health, Fujian Medical University, Fuzhou, Fujian Province, China. lhy@fjmu.edu.cn.
Fujian Medical University · CN

Funding

national natural science foundation of china 22006019national natural science foundation of china 81903352national natural science foundation of china 81973083national natural science foundation of china 82173553natural science foundation of zhejiang province LQ19H260002ningbo natural science foundation 2018A610317the joint funds for the innovation of science and technology, fujian province 2017Y9105the joint funds for the innovation of science and technology, fujian province 2018Y9098the joint funds for the innovation of science and technology, fujian province 2019Y9020the provincial natural science foundation of fujian province 2019J05081the provincial natural science foundation of fujian province 2020J02021
6 · The paper itself

Abstract

Neurodegenerative diseases are becoming major socio-economic burdens. However, most of them still have no effective treatment. Growing evidence indicates excess exposure to pesticides are involved in the development of various forms of neurodegenerative and neurological diseases through trigger epigenetic changes and inducing disruption of the epigenome. This review summaries studies on epigenetics alterations in nervous systems in relation to different kinds of pesticides, highlighting potential mechanism in the etiology, precision prevention and target therapy of various neurodegenerative diseases. In addition, the current gaps in research and future areas for study were also discussed.

Indexed as

DNA methylationEnvironmental pollutionEpigeneticHistone modificationsN6-methyladenosineNervous systemNeurodegenerative diseaseNon-coding RNAPesticideRNA methylation

Identifiers

PMID34893084
PMCPMC8662853
OpenAlexW4200531952

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.