Evidence map›Paper›PMID 34893031›Full record

ArticleBMC neurology2021

Latent profile analysis of cognitive decline and depressive symptoms after intracerebral hemorrhage.

Sophia Keins, Jessica R Abramson, Juan Pablo Castello, Marco Pasi, Andreas Charidimou, Christina Kourkoulis, Zora DiPucchio, Kristin Schwab, Christopher D Anderson, M Edip Gurol and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.3field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Post-stroke cognitive impairment: More than a lesion-symptom model.Imaging neuroscience (Cambridge, Mass.) · 2025
    Article
  7. Article
  8. Article
  9. Main features of hereditary cerebral amyloid angiopathies: A systematic review.Cerebral circulation - cognition and behavior · 2022
    Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 2 countries.

Sophia KeinsDepartment of Neurology, Massachusetts General Hospital, 100 Cambridge Street - Room 2064, Boston, MA, 02114, USA.
Jessica R AbramsonDepartment of Neurology, Massachusetts General Hospital, 100 Cambridge Street - Room 2064, Boston, MA, 02114, USA.
Juan Pablo CastelloDepartment of Neurology, Massachusetts General Hospital, 100 Cambridge Street - Room 2064, Boston, MA, 02114, USA.
Marco PasiDepartment of Neurology, Massachusetts General Hospital, 100 Cambridge Street - Room 2064, Boston, MA, 02114, USA.
Andreas CharidimouDepartment of Neurology, Massachusetts General Hospital, 100 Cambridge Street - Room 2064, Boston, MA, 02114, USA.
Christina KourkoulisDepartment of Neurology, Massachusetts General Hospital, 100 Cambridge Street - Room 2064, Boston, MA, 02114, USA.
Zora DiPucchioDepartment of Neurology, Massachusetts General Hospital, 100 Cambridge Street - Room 2064, Boston, MA, 02114, USA.
Kristin SchwabDepartment of Neurology, Massachusetts General Hospital, 100 Cambridge Street - Room 2064, Boston, MA, 02114, USA.
Christopher D AndersonDepartment of Neurology, Massachusetts General Hospital, 100 Cambridge Street - Room 2064, Boston, MA, 02114, USA.
M Edip GurolDepartment of Neurology, Massachusetts General Hospital, 100 Cambridge Street - Room 2064, Boston, MA, 02114, USA.
Steven M GreenbergDepartment of Neurology, Massachusetts General Hospital, 100 Cambridge Street - Room 2064, Boston, MA, 02114, USA.
Jonathan RosandDepartment of Neurology, Massachusetts General Hospital, 100 Cambridge Street - Room 2064, Boston, MA, 02114, USA.
Anand ViswanathanDepartment of Neurology, Massachusetts General Hospital, 100 Cambridge Street - Room 2064, Boston, MA, 02114, USA.
Alessandro BiffiDepartment of Neurology, Massachusetts General Hospital, 100 Cambridge Street - Room 2064, Boston, MA, 02114, USA. abiffi@partners.org.
Massachusetts General Hospital · US

Funding

Apathy and Depression following Intracerebral HemorrhageK23NS100816 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI BIFFI, ALESSANDRO · 2017 to 2021
$1.0M
NINDS NIH HHS K23 NS100816
6 · The paper itself

Abstract

backgroundCognitive impairment and depressive symptoms are highly prevalent after Intracerebral Hemorrhage (ICH). We leveraged Latent Profile Analysis (LPA) to identify profiles for cognitive decline and depression onset after ICH. We also investigated differences in clinical, genetic and neuroimaging characteristics across patients' profiles.

methodsWe analyzed data from the ICH study conducted at Massachusetts General Hospital between January 1998 and December 2019. We collected information from electronical health records, follow-up interviews, CT and MRI imaging, and APOE genotype. We conducted LPA and multinomial logistic regression analyses to: 1) identify distinct profiles for cognitive decline and depression onset after ICH; 2) identify clinical, neuroimaging and genetic factors predicting individuals' likelihood to express a specific profile.

resultsWe followed 784 ICH survivors for a median of 45.8 months. We identified four distinct profiles in cognitive and depressive symptoms after ICH: low depression and dementia risk, early-onset depression and dementia, late-onset depression and dementia, high depression with low dementia risk. Cerebral small vessel disease severity and APOE genotype were specifically associated with the late-onset profile (both p < 0.05). Acute hematoma characteristics (size, intraventricular extension) and functional disability were specifically associated with the early-onset profile (all p < 0.05).

conclusionWe identified four distinct profiles for cognitive and depressive symptoms after ICH, each displaying specific associations with individual patients' clinical, genetic and neuroimaging data. These associations reflect separate biological mechanisms influencing dementia and depression risk after ICH. Our findings support employing LPA in future ICH studies, and is likely applicable to stroke survivors at large.

Indexed as

Cerebral Small Vessel DiseasesCognitive DysfunctionCerebral HemorrhageDepressionHumansMagnetic Resonance ImagingCerebral small vessel diseaseIntracerebral hemorrhageMemory disordersMood disordersNeuropsychiatric outcomes

Identifiers

PMID34893031
PMCPMC8662844
OpenAlexW4200171066

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.