Evidence map›Paper›PMID 34891469›Full record

ArticleAnnual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference2021

Deep Learning on SDF for Classifying Brain Biomarkers.

Zhangsihao Yang, Jianfeng Wu, Paul M Thompson, Yalin Wang

Abstract read
In one paragraph

Article in Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Zhangsihao Yang
Jianfeng Wu
Paul M Thompson
Yalin Wang

Funding

Multi-Source Sparse Learning to Identify MCI and Predict DeclineRF1AG051710 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI THOMPSON, PAUL M, WANG, YALIN · 2016 to 2016
$2.8M
Predicting the early childhood outcomes of preterm brain shape abnormalitiesR01EB025032 · NIBIB · CHILDREN'S HOSPITAL OF LOS ANGELES · PI LEPORE, NATASHA · 2017 to 2020
$2.6M
Developing a Univariate Neurodegeneration Imaging Biomarker with Optimal TransportationR21AG065942 · NIA · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · PI WANG, YALIN · 2020 to 2020
$445k
NIA NIH HHS R21 AG065942NIA NIH HHS RF1 AG051710NIBIB NIH HHS R01 EB025032
6 · The paper itself

Abstract

Biomarkers are one of the primary medical signs to facilitate the early detection of Alzheimer's disease. The small beta-amyloid (Aβ) peptide is an important indicator for the disease. However, current methods to detect Aβ pathology are either invasive (lumbar puncture) or quite costly and not widely available (amyloid PET). Thus a less invasive and cheaper approach is demanded. MRI which has been used widely in preclinical AD has recently shown the capability to predict brain Aβ positivity. This motivates us to develop a method, SDF sparse convolution, taking MRI to predict Aβ positivity. We obtain subjects from the Alzheimer's Disease Neuroimaging Initiative (ADNI) and use our method to discriminate Aβ positivity. Theoretically, we provide analysis towards the understanding of what the network has learned. Empirically, it shows strong performance on par or even better than state of the art.

Indexed as

Alzheimer DiseaseDeep LearningBiomarkersBrainHumansNeuroimagingBiomarkers

Identifiers

PMID34891469
PMCPMC8669623

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.