Evidence map›Paper›PMID 34890555›Full record

ArticleCell2021

Xist nucleates local protein gradients to propagate silencing across the X chromosome.

Yolanda Markaki, Johnny Gan Chong, Yuying Wang, Elsie C Jacobson, Christy Luong, Shawn Y X Tan, Joanna W Jachowicz, Mackenzie Strehle, Davide Maestrini, Abhik K Banerjee and 8 more

Open access · bronzeAbstract readPublished Erratum
In one paragraph

Article in Cell, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
  2. The Biological Function of Genome Organization.International journal of molecular sciences · 2025
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors.

Yolanda Markaki
Johnny Gan Chong
Yuying Wang
Elsie C Jacobson
Christy Luong
Shawn Y X Tan
Joanna W Jachowicz
Mackenzie Strehle
Davide Maestrini
Abhik K Banerjee
Bhaven A Mistry
Iris Dror
Francois Dossin
Johannes Schӧneberg
Edith Heard
Mitchell Guttman
Tom Chou
Kathrin Plath

Funding

Elucidating an Xist-dependent program of sexually dimorphic alternative splicing in the mammalian brainR01MH109166 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BLACK, DOUGLAS L, PLATH, KATHRIN · 2016 to 2020
$3.3M
Mechanism of chromatin remodeling and gene silencing by the lncRNAs Xist and TsixR01GM115233 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI PLATH, KATHRIN · 2015 to 2018
$1.6M
Defining the role of the E3-ligase APC/C and ubiquitination in X-inactivationR21HD094172 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DREIER, LARS, PLATH, KATHRIN · 2018 to 2019
$429k
NICHD NIH HHS R21 HD094172NIGMS NIH HHS R01 GM115233NIMH NIH HHS R01 MH109166
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Identifiers

PMID34890555
PMCPMC8722464
OpenAlexW4226077922

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.