ArticlePlant physiology2021
The transcription factor ORA59 exhibits dual DNA binding specificity that differentially regulates ethylene- and jasmonic acid-induced genes in plant immunity.
Article in Plant physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 31 citations in OpenAlex.
- Metabolite-mediated plant immunity: From traditional defenders to artificial elicitors.Journal of integrative plant biology · 2026Review
- Studies on the Role and Function of miR3630-5p-VqNAC92-VqMYB14/VqRAP2.12-VqSTSs in Vitis quinquangularis Plant Immunity.Plant, cell & environment · 2026Article
- Specialized Metabolic Reprogramming in Plant Immunity: Biosynthetic Networks, Spatiotemporal Regulation, and Quantitative Defense.Plants (Basel, Switzerland) · 2026Review
- Cross-Regulation of Metabolic and Immune Pathways in Plants Under Hypoxic Conditions.Plants (Basel, Switzerland) · 2026Review
- Stress-Induced Plant Specialized Metabolism: Signaling, Multi-Omics Integration, and Plant-Derived Antimicrobial Metabolites to Combat Antimicrobial Resistance.Plants (Basel, Switzerland) · 2026Review
- AP2/ERF transcription factors regulate the biosynthesis of terpenoids, phenolics, and alkaloids in plants.Horticulture research · 2026Article
- The CsLOB1-CsERF027 Regulatory Module Positively Enhances Citrus Target Spot Disease Resistance by Regulating CsRAP2.3-CsERF1 Cascade.Plant biotechnology journal · 2025Article
- A VIGS-based leaf disc method reveals ethylene's crucial role in hydrangea leaf spot resistance.Plant cell reports · 2025Article
- BvHP4b gene in red beet promotes tuber enlargement and enhances resistance to Pst DC3000.BMC genomics · 2025Article
- The AP2/ERF transcription factor GmTINY mediates ethylene regulation of Rhg1-conferred resistance against soybean cyst nematode.Plant communications · 2025Article
- The N-degron pathway governs autophagy to promote thermotolerance in Arabidopsis.Nature communications · 2025Article
- Jasmonic Acid (JA) Signaling Pathway in Rice Defense Against Chilo suppressalis Infestation.Rice (New York, N.Y.) · 2025Review
- Genome-wide identification and characterization of transcription factors involved in defense responses against Sclerotinia sclerotiorum in Brassica juncea.Scientific reports · 2025Article
- Mechanism of endogenous hormones regulating gallic acid biosynthesis during the development of buds and leaves in tea plant (Frontiers in plant science · 2025Article
- Arabidopsis WRKY55 Transcription Factor Enhances Soft Rot Disease Resistance with ORA59.The plant pathology journal · 2024Article
- Identification, evolution, and expression of GDSL-type Esterase/Lipase (GELP) gene family in three cotton species: a bioinformatic analysis.BMC genomics · 2023Article
- Integrated Transcriptome and Metabolome Analyses Reveal Details of the Molecular Regulation of Resistance to Stem Nematode in Sweet Potato.Plants (Basel, Switzerland) · 2023Article
- Transcriptional regulation of plant innate immunity.Essays in biochemistry · 2022Review
- Interplay between phytohormone signalling pathways in plant defence - other than salicylic acid and jasmonic acid.Essays in biochemistry · 2022Article
- Phyto-Oxylipins as Key Regulators of Plant Resilience to Abiotic and Biotic Stress.Physiologia plantarumReview
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Authors and funding
13 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Jasmonic acid (JA) and ethylene (ET) signaling modulate plant defense against necrotrophic pathogens in a synergistic and interdependent manner, while JA and ET also have independent roles in certain processes, e.g. in responses to wounding and flooding, respectively. These hormone pathways lead to transcriptional reprogramming, which is a major part of plant immunity and requires the roles of transcription factors. ET response factors are responsible for the transcriptional regulation of JA/ET-responsive defense genes, of which ORA59 functions as a key regulator of this process and has been implicated in the JA-ET crosstalk. We previously demonstrated that Arabidopsis (Arabidopsis thaliana) GDSL LIPASE 1 (GLIP1) depends on ET for gene expression and pathogen resistance. Here, promoter analysis of GLIP1 revealed ERELEE4 as the critical cis-element for ET-responsive GLIP1 expression. In a yeast one-hybrid screening, ORA59 was isolated as a specific transcription factor that binds to the ERELEE4 element, in addition to the well-characterized GCC box. We found that ORA59 regulates JA/ET-responsive genes through direct binding to these elements in gene promoters. Notably, ORA59 exhibited a differential preference for GCC box and ERELEE4, depending on whether ORA59 activation is achieved by JA and ET, respectively. JA and ET induced ORA59 phosphorylation, which was required for both activity and specificity of ORA59. Furthermore, RNA-seq and virus-induced gene silencing analyses led to the identification of ORA59 target genes of distinct functional categories in JA and ET pathways. Our results provide insights into how ORA59 can generate specific patterns of gene expression dynamics through JA and ET hormone pathways.
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