ArticlePlant physiology2021
Two stripe rust effectors impair wheat resistance by suppressing import of host Fe-S protein into chloroplasts.
Article in Plant physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 61 citations in OpenAlex.
- Blue Light Receptor PHR2-Mediated Spectrum Antiviral Immunity.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Beyond R-Genes: Dissecting Metabolic and Nutrient-Driven Wheat Rust Resistance Through Induced Mutagenesis.Plants (Basel, Switzerland) · 2026Review
- Virulence gains in the Puccinia striiformis f. sp. tritici PstS10 lineage correlate with expression polymorphism in a candidate Avr effector.Communications biology · 2026Article
- Wheat transcriptome changes in response to the black stem rust pathogen (Puccinia graminis f. sp. tritici).BMC biotechnology · 2026Article
- To win the battle: the chloroplast is a key battleground in plant-pathogen interactions.Horticulture research · 2026Article
- The important role of chloroplasts in plant immunity.Plant communications · 2025Review
- Genomics Research on the Road of Studying Biology and Virulence of Cereal Rust Fungi.Molecular plant pathology · 2025Review
- A fungal pathogen suppresses host leaf senescence to increase infection.Nature communications · 2025Article
- Computational studies reveal structural characterization and novel families of Puccinia striiformis f. sp. tritici effectors.PLoS computational biology · 2025Article
- Uncovering the Mechanisms: The Role of Biotrophic Fungi in Activating or Suppressing Plant Defense Responses.Journal of fungi (Basel, Switzerland) · 2024Review
- The RING-finger ubiquitin E3 ligase TaPIR1 targets TaHRP1 for degradation to suppress chloroplast function.Nature communications · 2024Article
- Chloroplast protein StFC-II was manipulated by aHorticulture research · 2024Article
- Quantitative phosphoproteomics reveals molecular pathway network in wheat resistance to stripe rust.Stress biology · 2024Article
- Modern Breeding Strategies and Tools for Durable Late Blight Resistance in Potato.Plants (Basel, Switzerland) · 2024Review
- Small secreted effector protein from Fusarium sacchari suppresses host immune response by inhibiting ScPi21-induced cell death.Molecular plant pathology · 2024Article
- Stripe Rust Effector Pst_9302 Inhibits Wheat Immunity to Promote Susceptibility.Plants (Basel, Switzerland) · 2023Article
- Dynamic Reconfiguration of Switchgrass Proteomes in Response to Rust (International journal of molecular sciences · 2023Article
- The chloroplast protein HCF164 is predicted to be associated with Coffea SScientific reports · 2023Article
- An effector ofHorticulture research · 2023Article
- Photosynthesis, Water Status and KPlants (Basel, Switzerland) · 2023Article
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Several effectors from phytopathogens usually target various cell organelles to interfere with plant defenses, and they generally contain sequences that direct their translocation into organelles, such as chloroplasts. In this study, we characterized a different mechanism for effectors to attack chloroplasts in wheat (Triticum aestivum). Two effectors from Puccinia striiformis f. sp. tritici (Pst), Pst_4, and Pst_5, inhibit Bax-mediated cell death and plant immune responses, such as callose deposition and reactive oxygen species (ROS) accumulation. Gene silencing of the two effectors induced significant resistance to Pst, demonstrating that both effectors function as virulence factors of Pst. Although these two effectors have low sequence similarities and lack chloroplast transit peptides, they both interact with TaISP (wheat cytochrome b6-f complex iron-sulfur subunit, a chloroplast protein encoded by nuclear gene) in the cytoplasm. Silencing of TaISP impaired wheat resistance to avirulent Pst and resulted in less accumulation of ROS. Heterogeneous expression of TaISP enhanced chloroplast-derived ROS accumulation in Nicotiana benthamiana. Co-localization in N. benthamiana and western blot assay of TaISP content in wheat chloroplasts show that both effectors suppressed TaISP from entering chloroplasts. We conclude that these biotrophic fungal effectors suppress plant defenses by disrupting the sorting of chloroplast protein, thereby limiting host ROS accumulation and promoting fungal pathogenicity.
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