Evidence map›Paper›PMID 34890081›Full record

ArticlePaediatric and perinatal epidemiology2022

Air pollution and fecundability: Results from a Danish preconception cohort study.

Amelia K Wesselink, Tanran R Wang, Matthias Ketzel, Ellen M Mikkelsen, Jørgen Brandt, Jibran Khan, Ole Hertel, Anne Sofie D Laursen, Benjamin R Johannesen, Mary D Willis and 5 more

Abstract read
In one paragraph

Article in Paediatric and perinatal epidemiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Residential Exposure to PMPaediatric and perinatal epidemiology · 2025
    Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Review
  13. Article
  14. Air pollution and pregnancy.Seminars in perinatology · 2023
    Article
  15. Article
  16. Article
  17. Article
  18. Changes in tropospheric air quality related to the protection of stratospheric ozone in a changing climate.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2023
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Amelia K WesselinkDepartment of Epidemiology, Boston University School of Public Health, Boston, Massachusetts, USA.ORCID https://orcid.org/0000-0002-3929-4451
Tanran R WangDepartment of Epidemiology, Boston University School of Public Health, Boston, Massachusetts, USA.
Matthias KetzelDepartment of Environmental Science, Aarhus University, Roskilde, Denmark.
Ellen M MikkelsenDepartment of Clinical Epidemiology, Department of Clinical Medicine, Aarhus University and Aarhus University Hospital, Aarhus, Denmark.
Jørgen BrandtDepartment of Environmental Science, Aarhus University, Roskilde, Denmark.
Jibran KhanDepartment of Environmental Science, Aarhus University, Roskilde, Denmark.
Ole HertelDepartment of Ecoscience, Aarhus University, Denmark.
Anne Sofie D LaursenDepartment of Clinical Epidemiology, Department of Clinical Medicine, Aarhus University and Aarhus University Hospital, Aarhus, Denmark.
Benjamin R JohannesenDepartment of Clinical Epidemiology, Department of Clinical Medicine, Aarhus University and Aarhus University Hospital, Aarhus, Denmark.
Mary D WillisDepartment of Epidemiology, Boston University School of Public Health, Boston, Massachusetts, USA.
Jonathan I LevyDepartment of Environmental Health, Boston University School of Public Health, Boston, Massachusetts, USA.
Kenneth J RothmanDepartment of Epidemiology, Boston University School of Public Health, Boston, Massachusetts, USA.
Henrik T SørensenDepartment of Epidemiology, Boston University School of Public Health, Boston, Massachusetts, USA.
Lauren A WiseDepartment of Epidemiology, Boston University School of Public Health, Boston, Massachusetts, USA.ORCID https://orcid.org/0000-0003-2138-3752
Elizabeth E HatchDepartment of Epidemiology, Boston University School of Public Health, Boston, Massachusetts, USA.

Funding

An internet-based preconception cohort study in North America and DenmarkR01HD086742 · NICHD · BOSTON UNIVERSITY MEDICAL CAMPUS · PI LAUREN A WISE · 2016 to 2026
$6.7M
A preconception cohort study of air pollution, fertility, and miscarriageR01ES028923 · NIEHS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI LAUREN A WISE, Amelia Kent Wesselink · 2018 to 2026
$4.3M
NICHD NIH HHS R01 HD086742NIEHS NIH HHS R01 ES028923NIEHS NIH HHS R01-ES028923
6 · The paper itself

Abstract

backgroundAnimal and epidemiologic studies indicate that air pollution may adversely affect fertility. Epidemiologic studies have been restricted largely to couples undergoing fertility treatment or have retrospectively ascertained time-to-pregnancy among pregnant women.

objectivesWe examined the association between residential ambient air pollution and fecundability, the per-cycle probability of conception, in a large preconception cohort of Danish pregnancy planners.

methodsDuring 2007-2018, we used the Internet to recruit and follow women who were trying to conceive without the use of fertility treatment. Participants completed an online baseline questionnaire eliciting socio-demographic characteristics, lifestyle factors, and medical and reproductive histories and follow-up questionnaires every 8 weeks to ascertain pregnancy status. We determined concentrations of ambient nitrogen oxides (NO

resultsDuring 12 months of follow-up, 73% of participants conceived. Higher concentrations of PM

conclusionsIn this preconception cohort study of Danish women, residential exposures to PM

Indexed as

Air PollutantsAir PollutionCohort StudiesDenmarkFemaleHumansParticulate MatterPregnancyProspective StudiesRetrospective StudiesTime-to-PregnancyAir PollutantsParticulate Matterair pollutionfecundabilityparticulate matterpreconception cohorttime-to-pregnancytraffic

Identifiers

PMID34890081
PMCPMC8712376

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.