Evidence map›Paper›PMID 34890048›Full record

ArticleFEBS letters2022

The chromatin repressors EZH2 and Suv4-20h coregulate cell fate specification during hippocampal development.

Kai-Chun Chang, Christopher T Rhodes, Jesse Q Zhang, Madeleine C Moseley, Sandra M Cardona, Shu-Wei Angela Huang, Ashley Rawls, Vance P Lemmon, Mitchel S Berger, Adam R Abate and 1 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in FEBS letters, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Kai-Chun ChangDepartment of Bioengineering and Therapeutic Sciences, University of California at San Francisco, CA, USA.
Christopher T RhodesDepartment of Biology, University of Texas at San Antonio, One UTSA Circle, TX, USA.
Jesse Q ZhangDepartment of Bioengineering and Therapeutic Sciences, University of California at San Francisco, CA, USA.
Madeleine C MoseleyDepartment of Biology, University of Texas at San Antonio, One UTSA Circle, TX, USA.ORCID 0000-0003-2635-2779
Sandra M CardonaDepartment of Biology, University of Texas at San Antonio, One UTSA Circle, TX, USA.
Shu-Wei Angela HuangDepartment of Biology, University of Texas at San Antonio, One UTSA Circle, TX, USA.
Ashley RawlsDepartment of Biology, University of Texas at San Antonio, One UTSA Circle, TX, USA.
Vance P LemmonThe Miami Project to Cure Paralysis, University of Miami, FL, USA.
Mitchel S BergerDepartment of Neurological Surgery, University of California at San Francisco, CA, USA.
Adam R AbateDepartment of Bioengineering and Therapeutic Sciences, University of California at San Francisco, CA, USA.
Chin-Hsing Annie LinDepartment of Biology, University of Texas at San Antonio, One UTSA Circle, TX, USA.ORCID 0000-0002-8906-2077
The University of Texas at San Antonio · USUniversity of California, San Francisco · USEunice Kennedy Shriver National Institute of Child Health and Human Development · USNeurological Surgery · USUniversity of Miami · US

Funding

Gigapixel digital PCR in Giant Unilamellar VesiclesR01EB019453 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ABATE, ADAM R., CHIU, CHARLES YEN · 2014 to 2022
$3.9M
Aberrant Epigenetic Repression in Esophageal MalignancySC3GM112543 · NIGMS · UNIVERSITY OF TEXAS SAN ANTONIO · PI LIN, CHIN-HSING ANNIE · 2015 to 2018
$425k
NIBIB NIH HHS R01 EB019453NIGMS NIH HHS SC3 GM112543
6 · The paper itself

Abstract

The cell fate transition from radial glial-like (RGL) cells to neurons and astrocytes is crucial for development and pathological conditions. Two chromatin repressors-the enhancer of zeste homolog 2 and suppressor of variegation 4-20 homolog-are expressed in RGL cells in the hippocampus, implicating these epigenetic regulators in hippocampal cell fate commitment. Using a double knockout mouse model, we demonstrated that loss of both chromatin repressors in the RGL population leads to deficits in hippocampal development. Single-nuclei RNA-Seq revealed differential gene expression and provided mechanistic insight into how the two chromatin repressors are critical for the maintenance of cycling cells in the dentate gyrus as well as the balance of cell trajectories between neuronal and astroglial lineages.

Indexed as

ChromatinEnhancer of Zeste Homolog 2 ProteinHippocampusMice, KnockoutAnimalsAstrocytesCell DifferentiationCell LineageEpendymoglial CellsGene Expression Regulation, DevelopmentalHistone-Lysine N-MethyltransferaseJumonji Domain-Containing Histone DemethylasesMiceNeurogenesisNeuronsChromatinEnhancer of Zeste Homolog 2 ProteinEzh2 protein, mouseHistone-Lysine N-MethyltransferaseJumonji Domain-Containing Histone DemethylasesKdm6b protein, mouseenhancer of zeste homolog 2printed droplet microfluidicsradial glial-like cellssingle nuclei RNA-sequencingsuppressor of variegation 4-20 homolog 1

Identifiers

PMID34890048
PMCPMC12548543
OpenAlexW4200341806

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.