ArticleVirchows Archiv : an international journal of pathology2022
Low level of interobserver concordance in assessing histological subtype and tumor grade in patients with penile cancer may impair patient care.
Article in Virchows Archiv : an international journal of pathology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Retrospective Single Center Assessment of Routes to Penile Cancer Diagnosis and the Role of Penile Biopsy.International journal of urology : official journal of the Japanese Urological Association · 2026Observational
- New histological risk grading system for prediction of lymph node metastasis in patients with penile cancer.Virchows Archiv : an international journal of pathology · 2025Article
- HPV and Penile Cancer: Epidemiology, Risk Factors, and Clinical Insights.Pathogens (Basel, Switzerland) · 2024Review
- The clinical implication and translational research of OSCC differentiation.British journal of cancer · 2024Article
- Development and validation of a predictive model for penile cancer based on the surveillance, epidemiology, and end results database and multi-center cases.Journal of cancer research and clinical oncology · 2023Article
- Increased prevalence of human papillomavirus in fresh tissue from penile cancers compared to non-malignant penile samples: a case-control study.BMC cancer · 2022Article
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Abstract
Differentiation between penile squamous cell carcinoma patients who can benefit from limited organ-sparing surgery and those at significant risk of lymph node metastasis is based on histopathological prognostic factors including histological grade and tumor histological subtype. We examined levels of interobserver and intraobserver agreement in assessment of histological subtype and grade in 207 patients with penile squamous cell carcinoma. The cases were assessed by seven pathologists from three hospitals located in Sweden and Italy. There was poor to moderate concordance in assessing both histological subtype and grade, with Fleiss kappas of 0.25 (range: 0.02-0.48) and 0.23 (range: 0.07-0.55), respectively. When choosing HPV-associated and non-HPV-associated subtypes, interobserver concordance ranged from poor to good, with a Fleiss kappa value of 0.36 (range: 0.02-0.79). A re-review of the slides by two of the pathologists showed very good intraobserver concordance in assessing histological grade and subtype, with Cohen's kappa values of 0.94 and 0.91 for grade and 0.95 and 0.84 for subtype. Low interobserver concordance could lead to undertreatment and overtreatment of many patients with penile cancer, and brings into question the utility of tumor histological subtype and tumor grade in determining patient treatment in pT1 tumors.
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