Evidence map›Paper›PMID 34889115›Full record

ArticleJournal of the American Heart Association2021

Mechanical Thrombectomy Up to 24 Hours in Large Vessel Occlusions and Infarct Velocity Assessment.

Manabu Inoue, Takeshi Yoshimoto, Kanta Tanaka, Junpei Koge, Masayuki Shiozawa, Tatsuya Nishii, Yasutoshi Ohta, Tetsuya Fukuda, Tetsu Satow, Hiroharu Kataoka and 6 more

Open access · goldAbstract read
In one paragraph

Article in Journal of the American Heart Association, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 23 citations in OpenAlex.

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  3. Intravenous miR-30c therapy confers dual neurovascular protection and improves long-term recovery after ischemic stroke.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 2 countries.

Manabu InoueDepartment of Cerebrovascular Medicine National Cerebral and Cardiovascular Center Suita Japan.ORCID 0000-0001-5228-6643
Takeshi YoshimotoDepartment of Neurology National Cerebral and Cardiovascular Center Suita Japan.ORCID 0000-0003-3178-8171
Kanta TanakaDivision of Stroke Care Unit National Cerebral and Cardiovascular Center Suita Japan.ORCID 0000-0002-3291-5083
Junpei KogeDepartment of Cerebrovascular Medicine National Cerebral and Cardiovascular Center Suita Japan.
Masayuki ShiozawaDepartment of Cerebrovascular Medicine National Cerebral and Cardiovascular Center Suita Japan.ORCID 0000-0002-8071-7284
Tatsuya NishiiDepartment of Radiology National Cerebral and Cardiovascular Center Suita Japan.ORCID 0000-0001-8353-2181
Yasutoshi OhtaDepartment of Radiology National Cerebral and Cardiovascular Center Suita Japan.ORCID 0000-0001-8286-0271
Tetsuya FukudaDepartment of Radiology National Cerebral and Cardiovascular Center Suita Japan.
Tetsu SatowDepartment of Neurosurgery National Cerebral and Cardiovascular Center Suita Japan.ORCID 0000-0001-8136-5420
Hiroharu KataokaDepartment of Neurosurgery National Cerebral and Cardiovascular Center Suita Japan.
Hiroshi YamagamiDivision of Stroke Care Unit National Cerebral and Cardiovascular Center Suita Japan.ORCID 0000-0001-8133-3314
Masafumi IharaDepartment of Neurology National Cerebral and Cardiovascular Center Suita Japan.ORCID 0000-0002-7102-4048
Masatoshi KogaDepartment of Cerebrovascular Medicine National Cerebral and Cardiovascular Center Suita Japan.ORCID 0000-0002-6758-4026
Michael MlynashStanford Stroke Center Stanford University Stanford CA.ORCID 0000-0001-7483-8699
Gregory W AlbersStanford Stroke Center Stanford University Stanford CA.ORCID 0000-0003-0263-4632
Kazunori ToyodaDepartment of Cerebrovascular Medicine National Cerebral and Cardiovascular Center Suita Japan.ORCID 0000-0002-8346-9845
National Cerebral and Cardiovascular Center · JPStanford Medicine · USOsaka National Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background We retrospectively compared early- (<6 hours) versus late- (6-24 hours) presenting patients using perfusion-weighted imaging selection and evaluated clinical/radiographic outcomes. Methods and Results Large vessel occlusion patients treated with mechanical thrombectomy from August 2017 to July 2020 within 24 hours of onset were retrieved from a single-center database. Perfusion-weighted imaging was analyzed by automated software and final infarct volume was measured semi-automatically within 14 days. The primary end point was good outcome (modified Rankin Scale 0-2 at 90 days). Secondary end points were excellent outcome (modified Rankin Scale 0-1 at 90 days), symptomatic intracranial hemorrhage, and death. Clinical characteristics/radiological values including hypoperfusion volume and infarct growth velocity (baseline volume/onset-to-image time) were compared between the groups. Of 1294 patients, 118 patients were included. The median age was 74 years, baseline National Institutes of Health Stroke Scale score was 14, and core volume was 13 mL. The late-presenting group had more female patients (67% versus 31%, respectively;

Indexed as

Cerebral InfarctionStrokeThrombectomyAgedBlood Flow VelocityFemaleHumansMaleRetrospective StudiesTime FactorsTreatment Outcomeacute strokeinfarct sizeperfusion imagingthrombectomy

Identifiers

PMID34889115
PMCPMC9075240
OpenAlexW4200016506

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.