Evidence map›Paper›PMID 34889029›Full record

ArticleJournal of cellular and molecular medicine2022

Caveolin-1 negatively regulates inflammation and fibrosis in silicosis.

RongLing He, XiangNing Yuan, Xin Lv, QingXiang Liu, LiJian Tao, Jie Meng

Open access · goldAbstract read
In one paragraph

Article in Journal of cellular and molecular medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 36 citations in OpenAlex.

  1. Review
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  12. Effect of Sex Differences in Silicotic Mice.International journal of molecular sciences · 2022
    Article
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  15. Review
  16. Caveolin-1 negatively regulates inflammation and fibrosis in silicosis.Journal of cellular and molecular medicine · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

RongLing HeDepartment of Pulmonary and Critical Care Medicine, Third Xiangya Hospital, Central South University, Changsha, China.
XiangNing YuanDepartment of Pulmonary and Critical Care Medicine, Third Xiangya Hospital, Central South University, Changsha, China.
Xin LvDepartment of Pulmonary and Critical Care Medicine, Third Xiangya Hospital, Central South University, Changsha, China.
QingXiang LiuDepartment of Pulmonary and Critical Care Medicine, Third Xiangya Hospital, Central South University, Changsha, China.
LiJian TaoHunan Key Laboratory of Organ Fibrosis, Central South University, Changsha, China.
Jie MengDepartment of Pulmonary and Critical Care Medicine, Third Xiangya Hospital, Central South University, Changsha, China.ORCID 0000-0002-4402-1589
Central South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Inhalation of crystalline silica causes silicosis, the most common and serious occupational disease, which is characterized by progressive lung inflammation and fibrosis. Recent studies revealed the anti-inflammatory and anti-fibrosis role of Caveolin-1 (Cav-1) in lung, but this role in silicosis has not been investigated. Thus, this study evaluated Cav-1 regulatory effects in silicosis. It was found that Cav-1 levels were significantly reduced in the lung from silicosis patients and silicotic mice. The silicosis models were established in C57BL/6 (wild-type) and Cav-1 deficiency (Cav-1

Indexed as

Pulmonary FibrosisSilicosisAnimalsCaveolin 1Disease Models, AnimalFibrosisHumansInflammationLungMiceMice, Inbred C57BLSilicon DioxideCaveolin 1Silicon Dioxidecaveolin-1fibrosisinflammationsilicosis

Identifiers

PMID34889029
PMCPMC8742238
OpenAlexW4200232109

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.