Evidence map›Paper›PMID 34889013›Full record

ArticleAngewandte Chemie (International ed. in English)2022

A Dual-Color Fluorescent Probe Allows Simultaneous Imaging of Main and Papain-like Proteases of SARS-CoV-2-Infected Cells for Accurate Detection and Rapid Inhibitor Screening.

Yong Cheng, Raina M Borum, Alex E Clark, Zhicheng Jin, Colman Moore, Pavla Fajtová, Anthony J O'Donoghue, Aaron F Carlin, Jesse V Jokerst

Open access · greenAbstract read
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.

  1. Pooled it
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  7. Article
  8. Peptide Amphiphile Mediated Co-assembly for Nanoplasmonic Sensing.Angewandte Chemie (International ed. in English) · 2023
    Article
  9. Article
  10. Review of FRET biosensing and its application in biomolecular detection.American journal of translational research · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Yong ChengDepartment of NanoEngineering, University of California, San Diego, La Jolla, CA 92093, USA.ORCID 0000-0003-2137-7045
Raina M BorumDepartment of NanoEngineering, University of California, San Diego, La Jolla, CA 92093, USA.
Alex E ClarkDepartment of Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
Zhicheng JinDepartment of NanoEngineering, University of California, San Diego, La Jolla, CA 92093, USA.
Colman MooreDepartment of NanoEngineering, University of California, San Diego, La Jolla, CA 92093, USA.
Pavla FajtováSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA 92093, USA.
Anthony J O'DonoghueSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA 92093, USA.
Aaron F CarlinDepartment of Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
Jesse V JokerstDepartment of NanoEngineering, University of California, San Diego, La Jolla, CA 92093, USA.ORCID 0000-0003-2829-6408
University of California San Diego · US

Funding

U of Calif, San Diego Neuroscience Microscopy ImagingP30NS047101 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GLEESON, JOSEPH G, ZHENG, BINHAI · 2003 to 2022
$9.0M
Validation of Smart Masks for Surveillance of COVID-19R01DE031114 · NIDCR · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JOKERST, JESSE VINCENT · 2021 to 2023
$1.2M
Deconvolution of pro- and anti-viral responses to Dengue virus and Zika Virus infectionsK08AI130381 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CARLIN, AARON F. · 2019 to 2023
$1.0M
Cancer Researchers in Nanotechnology (CRIN)T32CA153915 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KUMMEL, ANDREW CLYDE, ZHANG, DONG-ER · 2017 to 2021
$994k
Non-Invasive Detection and Staging of Decubitus and Diabetic UlcersR21AG065776 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JOKERST, JESSE VINCENT · 2020 to 2021
$575k
Imaging SARS-CoV-2 proteases for spatio-temporal insight into Covid-19R21AI157957 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JOKERST, JESSE VINCENT · 2020 to 2020
$434k
NCI NIH HHS T32 CA153915NIAID NIH HHS K08 AI130381NIAID NIH HHS R21 AI157957NIA NIH HHS R21 AG065776NIA NIH HHS R21 AG065776-01S1NIDCR NIH HHS R01 DE031114NINDS NIH HHS NS047101NINDS NIH HHS P30 NS047101
6 · The paper itself

Abstract

The main protease (M

Indexed as

ColorCoronavirus 3C ProteasesCoronavirus Papain-Like ProteasesFluorescence Resonance Energy TransferFluorescent DyesHEK293 CellsHumansProtease InhibitorsSARS-CoV-23C-like proteinase, SARS-CoV-2Coronavirus 3C ProteasesCoronavirus Papain-Like ProteasesFluorescent DyesProtease InhibitorsInhibitor ScreeningMain ProteasePapain-Like ProteaseSARS-CoV-2Simultaneous Visualization

Identifiers

PMID34889013
PMCPMC8854376
OpenAlexW4200498204

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.