Evidence map›Paper›PMID 34888976›Full record

ReviewCell proliferation2022

Advances in single-cell sequencing and its application to musculoskeletal system research.

Yongxiang Zhang, Jingkai Wang, Chao Yu, Kaishun Xia, Biao Yang, Yuang Zhang, Liwei Ying, Chenggui Wang, Xianpeng Huang, Qixin Chen and 3 more

Abstract readReview
In one paragraph

Review in Cell proliferation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Bioengineering (Basel, Switzerland) · 2025
    Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Mapping Cell Atlases at the Single-Cell Level.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Review
  13. Review
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Yongxiang ZhangDepartment of Orthopedics Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Jingkai WangDepartment of Orthopedics Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Chao YuDepartment of Orthopedics Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Kaishun XiaDepartment of Orthopedics Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Biao YangDepartment of Orthopedics Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Yuang ZhangDepartment of Orthopedics Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Liwei YingDepartment of Orthopedics Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Chenggui WangDepartment of Orthopedics Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Xianpeng HuangDepartment of Orthopedics Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Qixin ChenDepartment of Orthopedics Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Li ShenDepartment of Orthopedics Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.ORCID https://orcid.org/0000-0002-5696-2191
Fangcai LiDepartment of Orthopedics Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Chengzhen LiangDepartment of Orthopedics Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.ORCID https://orcid.org/0000-0002-2948-2141

Funding

China Postdoctoral Science Foundation 2017M612011Health Foundation of Zhejiang Province 2018KY092Health Foundation of Zhejiang Province WKJ-ZJ-1903Medical and Health Innovation Talent Support Program of Zhejiang Province 2020RC011National Natural Science Foundation of China 21774109National Natural Science Foundation of China 51522304National Natural Science Foundation of China 51973188National Natural Science Foundation of China 81772379National Natural Science Foundation of China 81902238National Natural Science Foundation of China 81972096National Natural Science Foundation of China 82072465Nature Science Foundation of Zhejiang Province LQ18H060003Nature Science Foundation of Zhejiang Province LR18E030002Nature Science Foundation of Zhejiang Province LY18H060004Nature Science Foundation of Zhejiang Province LY19H060005Nature Science Foundation of Zhejiang Province Y20H060063Scientific Research Fund of Zhejiang Provincial Education Department Y201941476Zhejiang University Education Foundation Global Partnership Fund, a project supported by the Scientific Research Fund of Zhejiang Provincial Education Department Y201941476Zhejiang University Education Foundation Global Partnership Fund, a project supported by the Scientific Research Fund of Zhejiang Provincial Education Department Y201941491
6 · The paper itself

Abstract

In recent years, single-cell sequencing (SCS) technologies have continued to advance with improved operating procedures and reduced cost, leading to increasing practical adoption among researchers. These emerging technologies have superior abilities to analyse cell heterogeneity at a single-cell level, which have elevated multi-omics research to a higher level. In some fields of research, application of SCS has enabled many valuable discoveries, and musculoskeletal system offers typical examples. This article reviews some major scientific issues and recent advances in musculoskeletal system. In addition, combined with SCS technologies, the research of cell or tissue heterogeneity in limb development and various musculoskeletal system clinical diseases also provides new possibilities for treatment strategies. Finally, this article discusses the challenges and future development potential of SCS and recommends the direction of future applications of SCS to musculoskeletal medicine.

Indexed as

ResearchRNA-SeqSingle-Cell AnalysisAnimalsEpigenesis, GeneticHumansMusculoskeletal SystemTranscriptomecell heterogeneitymusculoskeletal systemsingle-cell multi-omicssingle-cell sequencing

Identifiers

PMID34888976
PMCPMC8780907

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.