Evidence map›Paper›PMID 34888965›Full record

ArticleMolecular ecology2022

Vitamin D status is heritable and under environment-dependent selection in the wild.

Alexandra M Sparks, Susan E Johnston, Ian Handel, Jill G Pilkington, Jacqueline Berry, Josephine M Pemberton, Daniel H Nussey, Richard J Mellanby

Open access · hybridAbstract read
In one paragraph

Article in Molecular ecology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Alexandra M SparksInstitute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Edinburgh, UK.ORCID 0000-0002-7697-4632
Susan E JohnstonInstitute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Edinburgh, UK.ORCID 0000-0002-5623-8902
Ian HandelRoyal (Dick) School of Veterinary Studies and The Roslin Institute, The University of Edinburgh, Hospital for Small Animals, Roslin, UK.ORCID 0000-0001-6407-4963
Jill G PilkingtonInstitute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Edinburgh, UK.
Jacqueline BerrySpecialist Assay Laboratory (Vitamin D), Clinical Biochemistry, Manchester Royal Infirmary, Manchester, UK.
Josephine M PembertonInstitute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Edinburgh, UK.ORCID 0000-0002-0075-1504
Daniel H NusseyInstitute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Edinburgh, UK.ORCID 0000-0002-9985-0317
Richard J MellanbyRoyal (Dick) School of Veterinary Studies and The Roslin Institute, The University of Edinburgh, Hospital for Small Animals, Roslin, UK.ORCID 0000-0002-3467-7007
University of Edinburgh · GBRoslin Institute · GBManchester Royal Infirmary · GBUniversity of Leeds · GB

Funding

Biotechnology and Biological Sciences Research Council BB/H021868/1Wellcome Trust 098493/Z/12/Z
6 · The paper itself

Abstract

Vitamin D has a well-established role in skeletal health and is increasingly linked to chronic disease and mortality in humans and companion animals. Despite the clear significance of vitamin D for health and obvious implications for fitness under natural conditions, no longitudinal study has tested whether the circulating concentration of vitamin D is under natural selection in the wild. Here, we show that concentrations of dietary-derived vitamin D

Indexed as

ErgocalciferolsVitamin DAdultAnimalsCholecalciferolFemaleHumansSheepCholecalciferolErgocalciferolsVitamin D25 hydroxyvitamin DfitnessGWASheritabilitySoay sheepvitamin D

Identifiers

PMID34888965
PMCPMC9545857
OpenAlexW4200008790

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.