Evidence map›Paper›PMID 34888829›Full record

ArticleAdvances in neurobiology2021

Astrocytes: The Housekeepers and Guardians of the CNS.

Alexei Verkhratsky, Vladimir Parpura, Baoman Li, Caterina Scuderi

Open access · greenAbstract read
In one paragraph

Article in Advances in neurobiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed
22.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 66 citations in OpenAlex.

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  9. Genetic Tools in Rodents to Study Cannabinoid Functions.Current topics in behavioral neurosciences · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 5 countries.

Alexei VerkhratskyFaculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK. alexej.verkhratsky@manchester.ac.uk.
Vladimir ParpuraDepartment of Neurobiology, The University of Alabama at Birmingham, Birmingham, AL, USA.
Baoman LiDepartment of Forensic Analytical Toxicology, School of Forensic Medicine, China Medical University, Shenyang, China.
Caterina ScuderiDepartment of Physiology and Pharmacology "Vittorio Erspamer", SAPIENZA University of Rome, Rome, Italy.
China Medical University · CNSapienza University of Rome · ITUniversity of Alabama at Birmingham · USUniversity of Manchester · GB

Funding

Connexin 43 Modulates Regulated ExocytosisR01GM123971 · NIGMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI GRAY, MICHELLE · 2019 to 2022
$1.3M
NIGMS NIH HHS R01 GM123971
6 · The paper itself

Abstract

Astroglia are a diverse group of cells in the central nervous system. They are of the ectodermal, neuroepithelial origin and vary in morphology and function, yet, they can be collectively defined as cells having principle function to maintain homeostasis of the central nervous system at all levels of organisation, including homeostasis of ions, pH and neurotransmitters; supplying neurones with metabolic substrates; supporting oligodendrocytes and axons; regulating synaptogenesis, neurogenesis, and formation and maintenance of the blood-brain barrier; contributing to operation of the glymphatic system; and regulation of systemic homeostasis being central chemosensors for oxygen, CO

Indexed as

AstrocytesSodiumCentral Nervous SystemHomeostasisNeuronsSodiumAstrogliaBrain homoeostasisCa2+ signallingIon channelsNa+ signallingNeurotransmitter receptorsSLC transporters

Identifiers

PMID34888829
PMCPMC9004589
OpenAlexW4206272053

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.