Evidence map›Paper›PMID 34888663›Full record

Trial reportThe Journal of clinical endocrinology and metabolism2022

Prebiotic to Improve Calcium Absorption in Postmenopausal Women After Gastric Bypass: A Randomized Controlled Trial.

Karin C Wu, Sisi Cao, Connie M Weaver, Nicole J King, Sheena Patel, Hillary Kingman, Deborah E Sellmeyer, Kathryn McCauley, Danny Li, Susan V Lynch and 10 more

Open access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Journal of clinical endocrinology and metabolism, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 17 citations in OpenAlex.

  1. Trial
  2. Review
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  6. Article
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  9. Review
  10. Precision nutrition in the context of bariatric surgery.Reviews in endocrine & metabolic disorders · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 6 institutions in 1 country.

Karin C WuDepartment of Medicine, University of California San Francisco, San Francisco, CA 94143, USA.ORCID 0000-0001-8615-2897
Sisi CaoDepartment of Nutrition Science, Purdue University, West Lafayette, IN 47907, USA.
Connie M WeaverDepartment of Nutrition Science, Purdue University, West Lafayette, IN 47907, USA.
Nicole J KingEndocrine Research Unit, San Francisco Veterans Affairs Health Care System, San Francisco, CA 94121, USA.
Sheena PatelCalifornia Pacific Medical Center Research Institute, San Francisco, CA 94107, USA.
Hillary KingmanEndocrine Research Unit, San Francisco Veterans Affairs Health Care System, San Francisco, CA 94121, USA.
Deborah E SellmeyerDepartment of Medicine, Stanford University School of Medicine, Palo Alto, CA 94305, USA.
Kathryn McCauleyDepartment of Medicine, University of California San Francisco, San Francisco, CA 94143, USA.
Danny LiDepartment of Medicine, University of California San Francisco, San Francisco, CA 94143, USA.
Susan V LynchDepartment of Medicine, University of California San Francisco, San Francisco, CA 94143, USA.
Tiffany Y KimDepartment of Medicine, University of California San Francisco, San Francisco, CA 94143, USA.
Dennis M BlackDepartment of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA 94143, USA.
Martin M ShaferDepartment of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA.
Mustafa ÖzçamDepartment of Medicine, University of California San Francisco, San Francisco, CA 94143, USA.
Din L LinDepartment of Medicine, University of California San Francisco, San Francisco, CA 94143, USA.
Stanley J RogersDepartment of Surgery, University of California San Francisco, San Francisco, CA 94143, USA.
Lygia StewartDepartment of Surgery, University of California San Francisco, San Francisco, CA 94143, USA.
Jonathan T CarterDepartment of Surgery, University of California San Francisco, San Francisco, CA 94143, USA.
Andrew M PosseltDepartment of Surgery, University of California San Francisco, San Francisco, CA 94143, USA.
Anne L SchaferDepartment of Medicine, University of California San Francisco, San Francisco, CA 94143, USA.
University of California, San Francisco · USPurdue University West Lafayette · USSan Francisco VA Health Care System · USCalifornia Pacific Medical Center · USStanford University · USUniversity of Wisconsin–Madison · US

Funding

Clinical and Translational Science InstituteUL1TR001872 · NCATS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI COLLARD, HAROLD R, JACOBY, VANESSA · 2016 to 2025
$112.1M
UCSF Nutrition Obesity Research CenterP30DK098722 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHRISTIAN VAISSE · 2015 to 2026
$14.6M
Skeletal Biology and Biomechanics (SBB) CoreP30AR075055 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI EDWARD C HSIAO · 2019 to 2026
$7.1M
Prebiotic Intervention to Improve Calcium Absorption After Gastric Bypass SurgeryR21DK112126 · NIDDK · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI SCHAFER, ANNE LOUISE · 2017 to 2018
$448k
CSRD VA IK2 CX001984NCATS NIH HHS UL1 TR001872NCATS NIH HHS UL1TR001872NIAMS NIH HHS P30 AR075055NIAMS NIH HHS P30AR075055NIDDK NIH HHS P30 DK098722NIDDK NIH HHS R21 DK112126NIDDK NIH HHS R21DK112126NIH HHS T32DK00741837VA 1IK2CX001984
6 · The paper itself

Abstract

contextThe adverse skeletal effects of Roux-en-Y gastric bypass (RYGB) are partly caused by intestinal calcium absorption decline. Prebiotics, such as soluble corn fiber (SCF), augment colonic calcium absorption in healthy individuals.

objectiveWe tested the effects of SCF on fractional calcium absorption (FCA), biochemical parameters, and the fecal microbiome in a post-RYGB population.

methodsRandomized, double-blind, placebo-controlled trial of 20 postmenopausal women with history of RYGB a mean 5 years prior; a 2-month course of 20 g/day SCF or maltodextrin placebo was taken orally. The main outcome measure was between-group difference in absolute change in FCA (primary outcome) and was measured with a gold standard dual stable isotope method. Other measures included tolerability, adherence, serum calciotropic hormones and bone turnover markers, and fecal microbial composition via 16S rRNA gene sequencing.

resultsMean FCA ± SD at baseline was low at 5.5 ± 5.1%. Comparing SCF to placebo, there was no between-group difference in mean (95% CI) change in FCA (+3.4 [-6.7, +13.6]%), nor in calciotropic hormones or bone turnover markers. The SCF group had a wider variation in FCA change than placebo (SD 13.4% vs 7.0%). Those with greater change in microbial composition following SCF treatment had greater increase in FCA (r2 = 0.72, P = 0.05). SCF adherence was high, and gastrointestinal symptoms were similar between groups.

conclusionNo between-group differences were observed in changes in FCA or calciotropic hormones, but wide CIs suggest a variable impact of SCF that may be due to the degree of gut microbiome alteration. Daily SCF consumption was well tolerated. Larger and longer-term studies are warranted.

Indexed as

Gastric BypassCalciumCalcium, DietaryFemaleHormonesHumansPostmenopausePrebioticsRNA, Ribosomal, 16SVitamin DCalciumCalcium, DietaryHormonesPrebioticsRNA, Ribosomal, 16SVitamin Dbariatric surgerycalcium absorptiongastric bypassobesityprebiotic

Identifiers

PMID34888663
PMCPMC8947782
OpenAlexW4200386720

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.