ArticleEuropean heart journal2022
Predictors of long-term mortality among perioperative survivors of Fontan operation.
Article in European heart journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Reduced Perfusion Pressure as a Predictor of Protein-Losing Enteropathy After Fontan Procedure: Beyond Central Venous Pressure.Pediatric cardiology · 2026Article
- Fenestration Re-creation for Early Fontan Deterioration: Long-Term Hemodynamic and Clinical Outcomes.Pediatric cardiology · 2026Article
- Unique Systemic Vasodilatation of Post-fontan Physiology Compared with Biventricular Physiology: How Different is it on the CI-SVRI Plot?Pediatric cardiology · 2026Article
- Prediction of Fontan failure and correlates of Fontan-associated liver disease severity using machine learning and radiomic features from multi-parametric abdominal MRI.Pediatric radiology · 2026Article
- Risk Factors for Adverse Outcomes in a Fontan Population.Pediatric cardiology · 2026Article
- Adults with Fontan circulation: prognostic value of exercise pulmonary vascular resistance index.European heart journal · 2026Article
- Association of Pre-Fontan Hemodynamics With Long-Term Outcomes After Fontan Palliation: A Study From the Pediatric Cardiac Care Consortium.Circulation · 2026Article
- Benefits of Chronic Atrial Pacing in Fontan Physiology with Sinus Node Dysfunction and Preserved Ejection Fraction: Novel Therapeutic Approach for Failing Fontan.Pediatric cardiology · 2026Article
- Are Arrhythmias Adequately Incorporated into Studies on Long-Term Outcomes After the Fontan Operation?Pediatric cardiology · 2026Review
- Echocardiographic measurement of inferior vena cava diameter for estimating central venous pressure in adult Fontan patients.European heart journal. Imaging methods and practice · 2025Article
- Reduced myocardial work in Fontan circulation: feasibility, reproducibility, and diagnostic performance.European heart journal. Imaging methods and practice · 2025Article
- A novel technique for non-invasive assessment of pulmonary artery pressure in patients after the Fontan procedure.European heart journal open · 2025Article
- Relationship Between Atrial Dysfunction and Atrial Arrhythmias in Adults With Fontan Palliation: Role of Atrial Strain Imaging.Journal of the American Heart Association · 2025Article
- Eight-Year Outcomes of Cardiosphere-Derived Cells in Single Ventricle Congenital Heart Disease.Journal of the American Heart Association · 2024Article
- Long-term Outcomes of Fontan Operation in Korea: Different Regions, Different Patients, Different Prognostic Factors?Korean circulation journal · 2024Article
- Use of the CardioMEMS Device in Children and Patients with Congenital Heart Disease: A Literature Review.Journal of clinical medicine · 2024Review
- Association of patient-level characteristics with long-term outcomes after Fontan palliation: Rationale, design, and baseline characteristics of the Pediatric Cardiac Care Consortium Fontan cohort study.American heart journal · 2024Article
- Sequential MRI Evaluation of Lymphatic Abnormalities over the Course of Fontan Completion.Radiology. Cardiothoracic imaging · 2024Article
- Ventricular Morphology and Outcomes in Fontan Circulation without Hypoplastic Left Heart Syndrome: A Single-Center's Experience.Reviews in cardiovascular medicine · 2024Article
- The effect of the conduit size on middle-term outcomes in patients with extracardiac total cavopulmonary connection.Interdisciplinary cardiovascular and thoracic surgery · 2024Article
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18 authors.
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No grant is acknowledged in the PubMed record.
Abstract
aimsThe criteria for 'good' Fontan haemodynamics have been poorly defined in relation to long-term outcomes. The aim of this study was to identify the risk factors for mortality among haemodynamic parameters obtained early after the Fontan operation. METHODS AND
resultsClinical data of all perioperative survivors of the Fontan operation performed before 2011, from nine institutions, were collected through a retrospective chart review. In total, 1260 patients were included. The median age at the time of Fontan operation was 3.6 years. Post-operative cardiac catheterization was conducted in 1117 patients at a median period of 1.0 years after the operation. During the median follow-up period of 10.2 years, 107 patients died. The mortality rates at 10, 20, and 25 years after the operation were 5%, 12%, and 22%, respectively. On multivariable analysis, older age at the time of the operation {≥15 years, hazard ratio (HR) [95% confidence interval (CI)]: 3.2 (1.7-5.9)} and haemodynamic parameters obtained at post-operative catheterization, such as low ejection fraction [<30%, HR (95% CI): 7.5 (3.2-18)], low systemic oxygen saturation [<80%, HR (95% CI): 3.8 (1.6-9.1)], high central venous pressure [≥16 mmHg, HR (95% CI): 2.3 (1.3-3.9)], and low mean systemic arterial pressure [<60 mmHg, HR (95% CI): 3.0 (1.4-6.2)] were identified as independent predictors of mortality. The predictive model based on these parameters had a c-index of 0.75 at 10 years.
conclusionsHaemodynamic parameters obtained at a median period of 1.0 years, post-operatively, can accurately identify patients with a high mortality risk, who may need intensive management to improve long-term outcomes.
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