Evidence map›Paper›PMID 34888522›Full record

ArticleFrontiers in computer science2021

A workflow for rapid unbiased quantification of fibrillar feature alignment in biological images.

Stefania Marcotti, Deandra Belo de Freitas, Lee D Troughton, Fiona N Kenny, Tanya J Shaw, Brian M Stramer, Patrick W Oakes

Abstract read
In one paragraph

Article in Frontiers in computer science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed.

  1. Article
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  4. Orientation-based evaluation of scleral collagen fibers in uveitic secondary glaucoma.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026
    Article
  5. Mechanically-induced Septin Networks Protect Nuclear Integrity.bioRxiv : the preprint server for biology · 2026
    Article
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  10. Mechanical Forces Guide Axon Growth through the Nigrostriatal Pathway in an Organotypic Model.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  11. Wnt Activation in Mature Dermal Adipocytes Leads to Lipodystrophy and Skin Fibrosis via ATGL-Dependent Lipolysis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Stefania MarcottiRandall Centre for Cell and Molecular Biophysics, King's College London, London, UK.
Deandra Belo de FreitasRandall Centre for Cell and Molecular Biophysics, King's College London, London, UK.
Lee D TroughtonDepartment of Cell and Molecular Physiology, Stritch School of Medicine, Loyola University Chicago, Maywood, Illinois, US.
Fiona N KennyRandall Centre for Cell and Molecular Biophysics, King's College London, London, UK.
Tanya J ShawCentre for Inflammation Biology & Cancer Immunology, King's College London, London, UK.
Brian M StramerRandall Centre for Cell and Molecular Biophysics, King's College London, London, UK.
Patrick W OakesDepartment of Cell and Molecular Physiology, Stritch School of Medicine, Loyola University Chicago, Maywood, Illinois, US.

Funding

Tissue regulation of T cell function - Reagents CoreP01AI102851 · NIAID · UNIVERSITY OF ROCHESTER · PI Deborah J Fowell · 2014 to 2026
$26.0M
NIAID NIH HHS P01 AI102851Wellcome Trust
6 · The paper itself

Abstract

Measuring the organisation of the cellular cytoskeleton and the surrounding extracellular matrix (ECM) is currently of wide interest as changes in both local and global alignment can highlight alterations in cellular functions and material properties of the extracellular environment. Different approaches have been developed to quantify these structures, typically based on fibre segmentation or on matrix representation and transformation of the image, each with its own advantages and disadvantages. Here we present

Indexed as

alignmentanisotropycytoskeletonextracellular matrix (ECM)Fast Fourier Transform (FFT)fibres

Identifiers

PMID34888522
PMCPMC8654057

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.