Evidence map›Paper›PMID 34888436›Full record

ArticleRheumatology advances in practice2021

The relationship between the nail and systemic enthesitis in psoriatic arthritis.

Ashley Elliott, Adrian Pendleton, Gary Wright, Madeleine Rooney

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Rheumatology advances in practice, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03955861 (An Observational Study Evaluating the Utility of Ultrasound Confirmed Enthesitis as a Prognostic Marker for Response to Biologic Therapy in Psoriatic Arthritis), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03955861 completednot on this map

An Observational Study Evaluating the Utility of Ultrasound Confirmed Enthesitis as a Prognostic Marker for Response to Biologic Therapy in Psoriatic Arthritis

TypeobservationalSponsorBelfast Health and Social Care TrustRan2019 to 2021Enrolled80ConditionsPsoriatic Arthritis, Psoriasis, EnthesitisArmsadalimumab, Certolizumab, Etanercept, Golimumab, Secukinumab
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Ashley ElliottCentre for Experimental Medicine, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast.
Adrian PendletonRheumatology Department, Musgrave Park Hospital, Belfast, UK.
Gary WrightRheumatology Department, Musgrave Park Hospital, Belfast, UK.
Madeleine RooneyCentre for Experimental Medicine, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast.
Musgrave Park Hospital · GBQueen's University Belfast · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivePsoriatic nail disease is more common in PsA than in isolated skin psoriasis (PsO). The nail is closely integrated to the DIP joint entheses. US data have shown that those patients with nail disease in PsO are more likely to have systemic enthesitis. We examined whether there was a relationship between nail disease, DIP enthesitis and systemic enthesitis in established PsA.

methodsForty-six PsA participants with nail disease underwent US scanning of the nail unit and the DIP entheses along with peripheral entheseal sites according to the Madrid sonographic enthesitis index (MASEI).

resultsAt the finger level, there was a mild to moderate correlation between nail US changes and both clinical nail disease and DIP enthesis changes (DIP US) [Spearman correlation (

conclusionThis study has demonstrated the utility of nail US imaging and the close relationship, on scanning, between the DIP entheses and the nail unit. In PsA, we have seen a correlation between active US changes at the nail and peripheral enthesitis, which requires further analysis.

trial registrationClinicalTrials.gov, https://clinicaltrials.gov, NCT03955861.

Indexed as

enthesitisonychopathypsoriasispsoriatic arthritisultrasound

Identifiers

PMID34888436
PMCPMC8651221
OpenAlexW4206608294

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.