ArticleAPL bioengineering2021
A suspended layer additive manufacturing approach to the bioprinting of tri-layered skin equivalents.
Article in APL bioengineering, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 26 citations in OpenAlex.
- Unconventional bioprinting modalities for advanced tissue biofabrication.Biomaterials · 2026Review
- Advances in Bioprinting to Model Immune-Mediated Skin Diseases.Advanced healthcare materials · 2026Review
- AlternativeExpert reviews in molecular medicine · 2026Review
- 3D bioprinted melanoma models: a novel paradigm for the assessment of anticancer strategies combining PDT and drug delivery systems.Biomedical engineering online · 2025Review
- Bioprinting for drug screening: A path toward reducing animal testing or redefining preclinical research?Bioactive materials · 2025Review
- Bioprinting a Tri-layered Skin Analogue.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Photodynamic Therapy as a Novel Therapeutic Modality Applying Quinizarin-Loaded Nanocapsules and 3D Bioprinting Skin Permeation for Inflammation Treatment.Pharmaceuticals (Basel, Switzerland) · 2024Article
- Embedded 3D bioprinting - An emerging strategy to fabricate biomimetic & large vascularized tissue constructs.Bioactive materials · 2024Review
- Development of a tissue-engineered skin model with epidermal, dermal and hypodermal components.In vitro models · 2023Article
- 3D bioprinting-a model for skin aging.Regenerative biomaterials · 2023Review
- Developing a bioink for single-step deposition and maturation of human epidermis.International journal of bioprinting · 2023Article
- Research progress and challenges of bioprinting in wound dressing and healing: Bibliometrics-based analysis and perspectives.International journal of bioprinting · 2023Review
- Novel Electrospun Polycaprolactone/Calcium Alginate Scaffolds for Skin Tissue Engineering.Materials (Basel, Switzerland) · 2022Article
- 3D bioprinting of skin equivalents: Towards functional wound healing models.Journal of tissue engineeringReview
Corrections and comments
- Erratum issued
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
Skin exhibits a complex structure consisting of three predominant layers (epidermis, dermis, and hypodermis). Extensive trauma may result in the loss of these structures and poor repair, in the longer term, forming scarred tissue and associated reduction in function. Although a number of skin replacements exist, there have been no solutions that recapitulate the chemical, mechanical, and biological roles that exist within native skin. This study reports the use of suspended layer additive manufacturing to produce a continuous tri-layered implant, which closely resembles human skin. Through careful control of the bioink composition, gradients (chemical and cellular) were formed throughout the printed construct. Culture of the model demonstrated that over 21 days, the cellular components played a key role in remodeling the supporting matrix into architectures comparable with those of healthy skin. Indeed, it has been demonstrated that even at seven days post-implantation, the integration of the implant had occurred, with mobilization of the adipose tissue from the surrounding tissue into the construct itself. As such, it is believed that these implants can facilitate healing, commencing from the fascia, up toward the skin surface-a mechanism recently shown to be key within deep wounds.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.