ArticlePhysics and imaging in radiation oncology2021
Treatment plan comparison of proton vs photon radiotherapy for lower-grade gliomas.
Article in Physics and imaging in radiation oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 17 citations in OpenAlex.
- A review on radiological properties of fused deposition modelling material for three-dimensional printing in proton and light ion beam therapy.Physics and imaging in radiation oncology · 2026Review
- Brain state theory as a comprehensive model for addressing the "non-eloquent" brain in glioma surgery.Journal of neuro-oncology · 2025Article
- Protons or Photons in Pituitary Neuroendocrine Tumors-That Is Not the Question.International journal of particle therapy · 2025Article
- Brain volume loss after cranial irradiation: a controlled comparison study between photon vs proton radiotherapy for WHO grade 2-3 gliomas.Journal of neuro-oncology · 2025Article
- Comparison of translation algorithms in determining maximum allowable CTV shifts for Real-Time Gated Proton Therapy (RGPT) robustness evaluation in prostate cancers.Journal of applied clinical medical physics · 2025Article
- Selection for proton radiotherapy of grade 1-3 glioma patients.Clinical and translational radiation oncology · 2024Article
- Repurposing DailyQA3 for an efficient and spot position sensitive daily quality assurance tool for proton therapy.Journal of applied clinical medical physics · 2024Article
- Comprehensive assessment of proton plans with three different beam delivery systems for multiple brain metastases.Journal of radiosurgery and SBRT · 2024Article
- Mitigating Radiotoxicity in the Central Nervous System: Role of Proton Therapy.Current treatment options in oncology · 2023Review
- Review
- Hippocampus sparing volumetric modulated arc therapy in patients with loco-regionally advanced oropharyngeal cancer.Physics and imaging in radiation oncology · 2022Article
Corrections and comments
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Authors and funding
13 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposePatients with lower-grade gliomas are long-term survivors after radiotherapy and may benefit from the reduced dose to normal tissue achievable with proton therapy. Here, we aimed to quantify differences in dose to the uninvolved brain and contralateral hippocampus and compare the risk of radiation-induced secondary cancer for photon and proton plans for lower-grade glioma patients. MATERIALS AND
methodsTwenty-three patients were included in this in-silico planning comparative study and had photon and proton plans calculated (50.4 Gy(RBE = 1.1), 28 Fx) applying similar dose constraints to the target and organs at risk. Automatically calculated photon plans were generated with a 3 mm margin from clinical target volume (CTV) to planning target volume. Manual proton plans were generated using robust optimisation on the CTV. Dose metrics of organs at risk were compared using population mean dose-volume histograms and Wilcoxon signed-rank test. Secondary cancer risk per 10,000 persons per year (PPY) was estimated using dose-volume data and a risk model for secondary cancer induction.
resultsCTV coverage (V95%>98%) was similar for the two treatment modalities. Mean dose (D
conclusionA significant reduction in mean dose to uninvolved brain and contralateral hippocampus was found with proton planning. The estimated secondary cancer risk was reduced with proton therapy.
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