Evidence map›Paper›PMID 34888351›Full record

ArticleFrontiers in molecular biosciences2021

miR-15a-3p Protects Against Isoniazid-Induced Liver Injury

Xinmei Li, Heng Zhang, Lin Xu, Yuan Jin, Jiao Luo, Chuanhai Li, Kunming Zhao, Yuxin Zheng, Dianke Yu, Yanjie Zhao

Open access · goldAbstract read
In one paragraph

Article in Frontiers in molecular biosciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

  1. Carbamate Prodrugs RestrictACS central science · 2025
    Article
  2. Precision Medicine Strategies to Improve Isoniazid Therapy in Patients with Tuberculosis.European journal of drug metabolism and pharmacokinetics · 2024
    Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Xinmei LiSchool of Public Health, Qingdao University, Qingdao, China.
Heng ZhangSchool of Public Health, Qingdao University, Qingdao, China.
Lin XuSchool of Public Health, Qingdao University, Qingdao, China.
Yuan JinSchool of Public Health, Qingdao University, Qingdao, China.
Jiao LuoSchool of Public Health, Qingdao University, Qingdao, China.
Chuanhai LiSchool of Public Health, Qingdao University, Qingdao, China.
Kunming ZhaoSchool of Public Health, Qingdao University, Qingdao, China.
Yuxin ZhengSchool of Public Health, Qingdao University, Qingdao, China.
Dianke YuSchool of Public Health, Qingdao University, Qingdao, China.
Yanjie ZhaoSchool of Public Health, Qingdao University, Qingdao, China.
Qingdao University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Isoniazid (INH), an effective first-line drug for tuberculosis treatment, has been reported to be associated with hepatotoxicity for decades, but the underlying mechanisms are poorly understood.

Indexed as

drug-induced liver injuryhsa-miR-15a-3pisoniazidN-acetyltransferase 2regulation

Identifiers

PMID34888351
PMCPMC8651391
OpenAlexW3216272229

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.