ReviewFrontiers in medicine2021
Chronic Kidney Disease and Arterial Stiffness: A Two-Way Path.
Review in Frontiers in medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
60 citing papers in PubMed, 3 syntheses or guidelines pooled it, 82 citations in OpenAlex.
- Pulse Wave Velocity, Mortality and Cardiovascular Disease in Chronic Kidney Disease: A Systematic Review and Meta-Analysis.European journal of clinical investigation · 2026Pooled it
- Pooled it
- Role of klotho and fibroblast growth factor 23 in arterial calcification, thickness, and stiffness: a meta-analysis of observational studies.Scientific reports · 2024Pooled it
- Association between renal vascular lesions and echocardiographic indices related to diastolic function in patients with diabetic nephropathy: a biopsy-based cross-sectional study.Renal failure · 2026Article
- Estimated Pulse Wave Velocity Is Associated with Early Renal Impairment in Non-Diabetic Hypertensive Patients.Journal of clinical hypertension (Greenwich, Conn.) · 2026Article
- Carotid Atherosclerosis in Chronic Kidney Disease: Pathophysiological Mechanisms, Prevention and Tailored Clinical Management.Journal of clinical medicine · 2026Review
- Integrating clinical, laboratory and quantitative CT features for predicting split renal function in urinary tract obstruction.BMC medical imaging · 2026Article
- Correlation of Early Vascular Aging Ambulatory Score with Kidney Damage in a Hypertensive Population: A Pilot Study.Life (Basel, Switzerland) · 2026Article
- Characterizing the Clinical, Vascular, and Functional Phenotype of Metabolic Acidosis in Kidney Transplantation: A Cross-Sectional Study.Journal of clinical medicine · 2026Article
- The Clinical Significance of the Morning Blood Pressure Surge in Chronic Kidney Disease: A Systematic Review.Cureus · 2026Review
- Mechanistic insights into PFAS derivatives-induced coronary heart disease and atherosclerotic renal artery stenosis via integrated network toxicology and molecular modeling.Toxicology research · 2026Article
- The Conventional and Alternative Therapeutic Approaches in Arterial Stiffness Management.Pharmaceutics · 2026Review
- Lower Selenoprotein P Is Independently Associated with Peripheral Arterial Disease in Peritoneal Dialysis.Diagnostics (Basel, Switzerland) · 2026Article
- The Spectrum of Motor Disorders in Patients with Chronic Kidney Disease: Pathogenic Mechanisms, Clinical Manifestations, and Therapeutic Strategies.Journal of clinical medicine · 2026Review
- Chronic Kidney disease and cognitive frailty in aging: molecular crosstalk and clinical implications.Frontiers in aging neuroscience · 2026Review
- The Prevalence and Correlates of Arterial Stiffness in Patients With Treated Hypertension: Oscillometric Pulse Wave Analysis During 24-h Ambulatory Blood Pressure Monitoring.International journal of hypertension · 2026Article
- Associations of C-reactive protein, triglyceride-glucose index, and the C-reactive protein-triglyceride glucose index with multistate trajectories in the cardiovascular-renal-diabetes cluster.Frontiers in endocrinology · 2026Article
- ILK Deletion Protects Against Chronic Kidney Disease-Associated Vascular Damage.International journal of molecular sciences · 2025Article
- Cf-PWV but not cr-PWV or cd-PWV is associated with cardiovascular mortality in patients with chronic kidney disease.BMC nephrology · 2025Article
- Ambulatory Blood Pressure Variability, Progression of Kidney Disease, and Cardiovascular Outcomes in the Chronic Renal Insufficiency Cohort.American journal of hypertension · 2025Observational
Corrections and comments
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Authors and funding
4 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The kidney-heart relationship has raised interest for the medical population since its vast and complex interaction significantly impacts health. Chronic kidney disease (CKD) generates vascular structure and function changes, with significant hemodynamic effects. The early arterial stiffening in CKD patients is a consequence of the interaction between oxidative stress and chronic vascular inflammation, leading to an accelerated deterioration of left ventricular function and alteration in tissue perfusion. CKD amplifies the inflammatory cascade's activation and is responsible for altering the endothelium function, increasing the vascular tone, wall thickening, and favors calcium deposits in the arterial wall. Simultaneously, the autonomic imbalance, and alteration in other hormonal systems, also favor the overactivation of inflammatory and fibrotic mediators. Thus, hormonal disarrangement also contributes to structural and functional lesions throughout the arterial wall. On the other hand, a rise in arterial stiffening and volume overload generates high left ventricular afterload. It increases the left ventricular burden with consequent myocardial remodeling, development of left ventricular hypertrophy and, in turn, heart failure. It is noteworthy that reduction in glomerular mass of renal diseases generates a compensatory glomerular filtration overdriven associated with large-arteries stiffness and high cardiovascular events. Furthermore, we consider that the consequent alterations of the arterial system's mechanical properties are crucial for altering tissue perfusion, mainly in low resistance. Thus, increasing the knowledge of these processes may help the reader to integrate them from a pathophysiological perspective, providing a comprehensive idea of this two-way path between arterial stiffness and renal dysfunction and their impact at the cardiovascular level.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.