Evidence map›Paper›PMID 34888158›Full record

ReviewWorld journal of critical care medicine2021

Extracorporeal membrane oxygenation and inhaled sedation in coronavirus disease 2019-related acute respiratory distress syndrome.

Martin Bellgardt, Dennis Özcelik, Andreas Friedrich Christoph Breuer-Kaiser, Claudia Steinfort, Thomas Georg Karl Breuer, Thomas Peter Weber, Jennifer Herzog-Niescery

Registry-linked trialOpen access · diamondAbstract readReview
In one paragraph

Review in World journal of critical care medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05680545 (Volatile Anesthetic Pharmacokinetics During Extracorporeal Membrane), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05680545 nanot yet recruitingnot on this mapstarted 2025, after this paper: background citation

Volatile Anesthetic Pharmacokinetics During Extracorporeal Membrane

TypeinterventionalSponsorUniversity Health Network, TorontoRan2025 to 2026Enrolled10ConditionsRespiratory FailureArmsSevoflurane vaporized in ECMO machines
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Martin BellgardtAnesthesia and Intensive Care Medicine, St. Josef-Hospital, University Hospital of Ruhr-University of Bochum, Bochum 44791, Germany. martin.bellgardt@rub.de.
Dennis ÖzcelikChemistry | Biology | Pharmacy Information Center, ETH Zürich, Zürich 8093, Switzerland.
Andreas Friedrich Christoph Breuer-KaiserAnesthesia and Intensive Care Medicine, St. Josef-Hospital, University Hospital of Ruhr-University of Bochum, Bochum 44791, Germany.
Claudia SteinfortGeneral and Visceral Surgery, St. Josef-Hospital, University Hospital of Ruhr-University of Bochum, Bochum 44791, Germany.
Thomas Georg Karl BreuerInternal Medicine/Intensive Care, St. Josef-Hospital, University Hospital of Ruhr-University of Bochum, Bochum 44791, Germany.
Thomas Peter WeberAnesthesia and Intensive Care Medicine, St. Josef-Hospital, University Hospital of Ruhr-University of Bochum, Bochum 44791, Germany.
Jennifer Herzog-NiesceryAnesthesia and Intensive Care Medicine, St. Josef-Hospital, University Hospital of Ruhr-University of Bochum, Bochum 44791, Germany.
St. Josef-Hospital · DEETH Zurich · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Coronavirus disease 2019 (COVID-19) related acute respiratory distress syndrome (ARDS) is a severe complication of infection with severe acute respiratory syndrome coronavirus 2, and the primary cause of death in the current pandemic. Critically ill patients often undergo extracorporeal membrane oxygenation (ECMO) therapy as the last resort over an extended period. ECMO therapy requires sedation of the patient, which is usually achieved by intravenous administration of sedatives. The shortage of intravenous sedative drugs due to the ongoing pandemic, and attempts to improve treatment outcome for COVID-19 patients, drove the application of inhaled sedation as a promising alternative for sedation during ECMO therapy. Administration of volatile anesthetics requires an appropriate delivery. Commercially available ones are the anesthetic gas reflection systems AnaConDa

Indexed as

Acute respiratory distress syndromeCOVID-19Critical careExtracorporeal membrane oxygenationInhaled sedationVolatile anesthetics

Identifiers

PMID34888158
PMCPMC8613718
OpenAlexW3213250438

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.