Evidence map›Paper›PMID 34888112›Full record

ArticleScience bulletin2020

Reprogramming of Ovarian Granulosa Cells by YAP1 Leads to Development of High-Grade Cancer with Mesenchymal Lineage and Serous Features.

Xiangmin Lv, Chunbo He, Cong Huang, Guohua Hua, Xingcheng Chen, Barbara K Timm, Victoria M Maclin, Abigail A Haggerty, Shelly K Aust, Denae M Golden and 12 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science bulletin, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
0.9field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
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  3. Article
  4. Article
  5. Hippo signaling in mammalian reproduction.Reproduction (Cambridge, England) · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 6 institutions in 2 countries.

Xiangmin LvVincent Center for Reproductive Biology, Department of Obstetrics and Gynecology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Chunbo HeOlson Center for Women's Health, Department of Obstetrics and Gynecology, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Cong HuangVincent Center for Reproductive Biology, Department of Obstetrics and Gynecology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Guohua HuaVincent Center for Reproductive Biology, Department of Obstetrics and Gynecology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Xingcheng ChenFred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Barbara K TimmHeartland Center for Reproductive Medicine, Omaha, NE 68198, USA.
Victoria M MaclinHeartland Center for Reproductive Medicine, Omaha, NE 68198, USA.
Abigail A HaggertyMunroe-Meyer Institute, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Shelly K AustMunroe-Meyer Institute, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Denae M GoldenMunroe-Meyer Institute, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Bhavana J DaveMunroe-Meyer Institute, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Yun-An TsengDepartment of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Li ChenVincent Center for Reproductive Biology, Department of Obstetrics and Gynecology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Hongbo WangVincent Center for Reproductive Biology, Department of Obstetrics and Gynecology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Peichao ChenVincent Center for Reproductive Biology, Department of Obstetrics and Gynecology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
David L KlinkebielBiochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Adam R KarpfFred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Jixin DongFred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Ronny I DrapkinDepartment of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, PA 19104, USA.
Bo R RuedaVincent Center for Reproductive Biology, Department of Obstetrics and Gynecology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
John S DavisOlson Center for Women's Health, Department of Obstetrics and Gynecology, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Cheng WangVincent Center for Reproductive Biology, Department of Obstetrics and Gynecology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Harvard University · USUniversity of Nebraska Medical Center · USNebraska Medical Center · USHuazhong Agricultural University · CNMassachusetts General Hospital · USUniversity of Pennsylvania · US

Funding

UNMC Structural Biology CoreP20GM103427 · NIGMS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI PAUL L SORGEN · 2012 to 2026
$59.2M
UNMC/EPPLEY CANCER CENTER SUPPORT GRANTP30CA036727 · NCI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI Joann B. Sweasy · 1985 to 2026
$55.0M
The Aging Pituitary/Gonadal AxisP01AG029531 · NIA · WICHITA STATE UNIVERSITY · PI CHITTIBABU GUDA · 2009 to 2026
$25.9M
Research Pilot Project ProgramP30GM106397 · NIGMS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI JOHNSON, KEITH R · 2013 to 2017
$4.9M
The Hippo/YAP Signaling Pathway in Ovarian High Grade Serous CarcinomaR01CA197976 · NCI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI WANG, CHENG · 2016 to 2025
$4.0M
Novel Mechanisms of Cervical Cancer Development and ProgressionR01CA201500 · NCI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI WANG, CHENG · 2016 to 2020
$1.8M
GPR30 Mediated-Estrogen Action on Ovarian Physiology and Ovarian CancerR00HD059985 · NICHD · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI WANG, CHENG · 2012 to 2014
$716k
BLRD VA I01 BX004272BLRD VA IK6 BX005797NCI NIH HHS P30 CA036727NCI NIH HHS R01 CA197976NCI NIH HHS R01 CA201500NIA NIH HHS P01 AG029531NICHD NIH HHS R00 HD059985NIGMS NIH HHS P20 GM103427NIGMS NIH HHS P30 GM106397
6 · The paper itself

Abstract

Understanding the cell-of-origin of ovarian high grade serous cancer (HGSC) is the prerequisite for efficient prevention and early diagnosis of this most lethal gynecological cancer. Recently, a mesenchymal type of ovarian HGSC with the poorest prognosis among ovarian cancers was identified by both TCGA and AOCS studies. The cell-of-origin of this subtype of ovarian cancer is unknown. While pursuing studies to understand the role of the Hippo pathway in ovarian granulosa cell physiology and pathology, we unexpectedly found that the Yes-associated protein 1 (YAP1), the major effector of the Hippo signaling pathway, induced dedifferentiation and reprogramming of the ovarian granulosa cells, a unique type of ovarian follicular cells with mesenchymal lineage and high plasticity, leading to the development of high grade ovarian cancer with serous features. Our research results unveil a potential cell-of-origin for a subtype of HGSC with mesenchymal features.

Indexed as

cell dedifferentiationcell reprogrammingMesenchymal type of high grade serous cancerOvarian granulosa cellsthe Hippo pathwayYAP1 oncogene

Identifiers

PMID34888112
PMCPMC8654108
OpenAlexW3014445977

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.